Serum metabolomic profiling facilitates the non-invasive identification of metabolic biomarkers associated with the onset and progression of non-small cell lung cancer

被引:82
作者
Puchades-Carrasco, Leonor [1 ]
Jantus-Lewintre, Eloisa [2 ]
Perez-Rambla, Clara [1 ,2 ,3 ]
Garcia-Garcia, Francisco [4 ]
Lucas, Rut [2 ]
Calabuig, Silvia [2 ]
Blasco, Ana [5 ]
Dopazo, Joaqun [4 ,6 ,7 ]
Camps, Carlos [2 ,5 ,8 ]
Pineda-Lucena, Antonio [1 ,3 ]
机构
[1] Ctr Invest Principe Felipe, Struct Biochem Lab, Valencia, Spain
[2] Fdn Invest Hosp Gen Univ, Mol Oncol Lab, Valencia, Spain
[3] Hosp Univ & Politecn La Fe, Inst Invest Sanitaria La Fe, Valencia, Spain
[4] Ctr Invest Principe Felipe, Computat Genom Dept, Valencia, Spain
[5] Consorcio Hosp Gen Univ, Dept Med Oncol, Valencia, Spain
[6] CIBER Enfermedades Raras CIBERER, Bioinformat Rare Dis BIER, Valencia, Spain
[7] Ctr Invest Principe Felipe, Inst Nacl Bioinformat, Funct Genom Node, Valencia, Spain
[8] Univ Valencia, Dept Med, Valencia, Spain
关键词
NSCLC; metabolomics; biomarkers; early diagnosis; prognosis; CHOLINE KINASE ALPHA; AMINO-ACID; NMR-SPECTROSCOPY; CARCINOMA; H-1;
D O I
10.18632/oncotarget.7354
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Lung cancer (LC) is responsible for most cancer deaths. One of the main factors contributing to the lethality of this disease is the fact that a large proportion of patients are diagnosed at advanced stages when a clinical intervention is unlikely to succeed. In this study, we evaluated the potential of metabolomics by H-1-NMR to facilitate the identification of accurate and reliable biomarkers to support the early diagnosis and prognosis of non-small cell lung cancer (NSCLC). We found that the metabolic profile of NSCLC patients, compared with healthy individuals, is characterized by statistically significant changes in the concentration of 18 metabolites representing different amino acids, organic acids and alcohols, as well as different lipids and molecules involved in lipid metabolism. Furthermore, the analysis of the differences between the metabolic profiles of NSCLC patients at different stages of the disease revealed the existence of 17 metabolites involved in metabolic changes associated with disease progression. Our results underscore the potential of metabolomics profiling to uncover pathophysiological mechanisms that could be useful to objectively discriminate NSCLC patients from healthy individuals, as well as between different stages of the disease.
引用
收藏
页码:12904 / 12916
页数:13
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