Design of experiments (DoE) to develop and to optimize nanoparticles as drug delivery systems

被引：115

作者：

Luiz, Marcela Tavares ^{[1
]}

Viegas, Juliana Santos Rosa ^{[1
]}

Abriata, Juliana Palma ^{[1
]}

Viegas, Felipe ^{[2
]}

Vicentini, Fabiana Testa Moura de Carvalho ^{[1
]}

Bentley, Maria Vitoria Lopes Badra ^{[1
]}

Chorilli, Marlus ^{[3
]}

Marchetti, Juliana Maldonado ^{[1
]}

Tapia-Blacido, Delia Rita ^{[4
]}

机构：

[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Ribeirao Preto, SP, Brazil

[2] Univ Fed Minas Gerais, Dept Comp Sci, Belo Horizonte, MG, Brazil

[3] Sao Paulo State Univ, Sch Pharmaceut Sci, Araraquara, SP, Brazil

[4] Univ Sao Paulo, Dept Chem, Fac Philosophy Sci & Letters Ribeirao Preto, Av Bandeirantes 3900, BR-14040901 Ribeirao Preto, SP, Brazil

来源：

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 2021年 / 165卷

关键词：

Box-Behnken Design; Central Composite Design; Full Factorial Design; Fractional Factorial Design; Nanomedicine; Nanotechnology; Plackett-Burman Design; Response Surface Methodology; Quality by Design; NANOSTRUCTURED LIPID CARRIERS; BOX-BEHNKEN DESIGN; QUALITY-BY-DESIGN; RESPONSE-SURFACE METHODOLOGY; CENTRAL COMPOSITE DESIGN; POLYMER HYBRID NANOPARTICLES; IN-VITRO CHARACTERIZATION; IRON-OXIDE NANOPARTICLES; ORAL BIOAVAILABILITY; GOLD NANOPARTICLES;

D O I：

10.1016/j.ejpb.2021.05.011

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nanotechnology has been widely applied to develop drug delivery systems to improve therapeutic performance. The effectiveness of these systems is intrinsically related to their physicochemical properties, so their biological responses are highly susceptible to factors such as the type and quantity of each material that is employed in their synthesis and to the method that is used to produce them. In this context, quality-oriented manufacturing of nanoparticles has been an important strategy to understand and to optimize the factors involved in their production. For this purpose, Design of Experiment (DoE) tools have been applied to obtain enough knowledge about the process and hence achieve high-quality products. This review aims to set up the bases to implement DoE as a strategy to improve the manufacture of nanocarriers and to discuss the main factors involved in the production of the most common nanocarriers employed in the pharmaceutical field.

引用

页码：127 / 148

页数：22

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