Eruptive latent metastatic melanomas after initiation of antitumor necrosis factor therapies

被引：75
作者：
Fulchiero, Gregory J., Jr.
Salvaggio, Heather
Drabick, Joseph J.
Staveley-O'Carroll, Kevin
Billingsley, Elizabeth M.
Marks, James G.
Helm, Klaus F.
机构：
[1] Penn State Univ, Milton S Hershey Med Ctr, Dept Dermatol, Hershey, PA 17033 USA
[2] Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Hershey, PA 17033 USA
[3] Penn State Univ, Milton S Hershey Med Ctr, Dept Med, Hershey, PA 17033 USA
[4] Penn State Univ, Milton S Hershey Med Ctr, Dept Surg, Hershey, PA 17033 USA
[5] Penn State Univ, Milton S Hershey Med Ctr, Dept Pathol, Hershey, PA 17033 USA
来源：
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2007年 / 56卷 / 05期
关键词：
D O I：
10.1016/j.jaad.2006.12.024
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
We report two cases of late recurrence of eruptive locoregional metastatic melonoma occuring 6 and 9 years after definitive surgical treatment. Each case (stage IB and IA) occurred after initiation of the subcutaneous anti-tumor necrosis factor medication etanercept and adalimumab, respectively. We discuss the association of immune suppression and melonoma. These cases illustrate a previously unrecognized and potentially causal relationship between tumor necrosis factor-alpha inhibition and reactivation of latent melanoma.
引用
收藏
页码：S65 / S67
页数：3
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