Point-of-care Arkansas method for measuring adherence to treatment with isoniazid

被引：24

作者：

Guerra, Renata L. ^{[1
]}

Conde, Marcus B.

Efron, Anne ^{[2
]}

Loredo, Carla

Bastos, Gisele

Chaisson, Richard E. ^{[2
]}

Golub, Jonathan E. ^{[2
]}

机构：

[1] Univ Fed Rio de Janeiro, Clementino Fraga Filho Univ Hosp, Inst Thorac Dis, TB Clin Res Lab, BR-21941913 Rio De Janeiro, Brazil

[2] Johns Hopkins Univ, Sch Med, Baltimore, MD USA

来源：

RESPIRATORY MEDICINE | 2010年 / 104卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Latent tuberculosis infection; Isoniazid; Adherence; Arkansas method; PREVENTIVE THERAPY; MONITOR ADHERENCE; URINE;

D O I：

10.1016/j.rmed.2010.02.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We evaluated the accuracy of a point-of-care test designed to measure adherence to isoniazid (INH) preventive therapy in a hospital setting in Rio de Janeiro, Brazil. Patients on treatment with daily INH and patients not receiving INH were included. Sensitivity and specificity of the test were 84%/98% at the first minute, and 95%/98% at the fifth minute, respectively. Among smokers, sensitivity and specificity was reduced (80%/89% at the fifth minute, respectively), but only 17% smoked. This test accurately detected INH metabolites 24 h following directly observed INH intake, though sensitivity and specificity may be compromised by tobacco smoke exposure. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：754 / 757

页数：4

共 11 条

[1] Efficacy of secondary isoniazid preventive therapy among HIV-infected Southern Africans: time to change policy? [J].

Churchyard, GJ ;

Fielding, K ;

Charalambous, S ;

Day, JH ;

Corbett, EL ;

Hayes, RJ ;

Chaisson, RE ;

De Cock, KM ;

Samb, B ;

Grant, AD .

AIDS, 2003, 17 (14) :2063-2070

[2] Use of the urine color test to monitor compliance with isoniazid treatment of latent tuberculosis infection [J].

Eidlitz-Markus, T ;

Zeharia, A ;

Baum, G ;

Mimouni, M ;

Amir, J .

CHEST, 2003, 123 (03) :736-739

[3] Monitoring compliance with antituberculous treatment by detection of isoniazid in urine [J].

Elizaga, J ;

Friedland, JS .

LANCET, 1997, 350 (9086) :1225-1226

[4]

ELLARD GA, 1980, BRIT J CLIN PHARMACO, V10, P369

[5]

Hanifa Y, 2007, INT J TUBERC LUNG D, V11, P1232

[6] Statistical design of THRio: a phased implementation clinic-randomized study of a tuberculosis preventive therapy intervention [J].

Moulton, Lawrence H. ;

Golub, Jonathan E. ;

Durovni, Betina ;

Cavalcante, Solange C. ;

Pacheco, Antonio G. ;

Saraceni, Valeria ;

King, Bonnie ;

Chaisson, Richard E. .

CLINICAL TRIALS, 2007, 4 (02) :190-199

[7] Urine testing to monitor adherence to TB preventive therapy [J].

Perry, S ;

Hovell, MF ;

Blumberg, E ;

Berg, J ;

Vera, A ;

Sipan, C ;

Kelley, N ;

Moser, K ;

Catanzaro, A ;

Friedman, L .

JOURNAL OF CLINICAL EPIDEMIOLOGY, 2002, 55 (03) :235-238

[8] TESTING FOR ISONIAZID - AN EVALUATION OF THE ARKANSAS METHOD [J].

SCHRAUFNAGEL, DE ;

STONER, R ;

WHITING, E ;

SNUKSTTORBECK, G ;

WERHANE, MJ .

CHEST, 1990, 98 (02) :314-316

[9]

White MC, 1998, INT J TUBERC LUNG D, V2, P506

[10] Point-of-care test to monitor adherence to anti-tuberculous treatment [J].

Whitfield, R ;

Cope, GF .

ANNALS OF CLINICAL BIOCHEMISTRY, 2004, 41 :411-413

← 1 2 →