Detection of Torque teno virus in Epstein-Barr virus positive and negative lymph nodes of patients with Hodgkin lymphoma

被引：20

作者：

Figueiredo, Claudia P.

Franz-Vasconcelos, Helena C. F.

Di Giunta, Gabriella

Mazzuco, Tania L.

Caon, Thiago

Fernandes, Andre L. M.

Simoes, Claudia M. O.

Antunes, Victor L. S.

Niel, Christian ^{[1
]}

Barardi, Celia R. M.

机构：

[1] Fiocruz MS, Dept Virol, Inst Oswaldo Cruz, BR-21045900 Rio De Janeiro, Brazil

[2] Univ Fed Santa Catarina, Serv Anat Patol, Hosp Univ, Florianopolis, SC, Brazil

[3] Univ Fed Santa Catarina, Dept Microbiol & Parasitol, Ctr Ciencias Biol, Florianopolis, SC, Brazil

[4] Univ Fed Santa Catarina, Dept Anal Clin, Ctr Ciencias Saude, Florianopolis, SC, Brazil

[5] Univ Fed Santa Catarina, Dept Farmacol, Ctr Ciencias Biol, Florianopolis, SC, Brazil

[6] Univ Fed Santa Catarina, Dept Ciencias Farmaceut, Ctr Ciencias Saude, Florianopolis, SC, Brazil

来源：

LEUKEMIA & LYMPHOMA | 2007年 / 48卷 / 04期

关键词：

Brazil; Hodgkin lymphoma; Epstein-Barr virus; lymph nodes; Torque teno virus;

D O I：

10.1080/10428190701203954

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The age-specific incidence of Hodgkin lymphoma (HL) is bimodal with peaks occurring among young adults (15 - 34 years old) and people older than 45 years. Epstein-Barr virus (EBV) is associated with only one-third of HL cases. This study sought to determine if Torque teno virus (TTV) might be independently associated with HL. The presence of EBV was appraised by in situ hybridization and immunohistochemistry in lymph node biopsies from 46 patients (3 - 81 years old) with HL. TTV DNA was assessed by PCR amplification. EBV was detected in 22 (48%) patients. TTV DNA was detected in 24/46 (52%) patients, as well as in 12/20 (60%) control patients with lymphoid unspecific hyperplasia. TTV DNA was not significantly more frequent in EBV negative (54%) than in EBV positive (50%) nodes. However, it was observed that the group of young adults (15 - 34 years, n = 19) showed the lowest EBV frequency (21%) but the highest TTV occurrence (60%). This may suggest an involvement of TTV infection in the pathogenesis of HL in young adults. Further large population-based studies are required to confirm our findings.

引用

页码：731 / 735

页数：5

共 29 条

[11] Isolation of multiple TT virus genotypes from spleen biopsy tissue from a Hodgkin's disease patient: Genome reorganization and diversity in the hypervariable region [J].