A Versatile Integrated Ambient Ionization Source Platform

被引:12
作者
Ai, Wanpeng [1 ]
Nie, Honggang [1 ]
Song, Shiyao [1 ]
Liu, Xiaoyun [1 ]
Bai, Yu [1 ]
Liu, Huwei [1 ]
机构
[1] Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Inst Analyt Chem,Coll Chem & Mol Engn, Beijing 100871, Peoples R China
基金
中国国家自然科学基金;
关键词
Combined ion source; Ambient source; High-throughput screening; Mechanism; DESORPTION ELECTROSPRAY-IONIZATION; DESORPTION/IONIZATION MASS-SPECTROMETRY; ATMOSPHERIC-PRESSURE; ION-SOURCE; NONPOLAR COMPOUNDS; OPEN-AIR; MIXTURES; PROBE;
D O I
10.1007/s13361-018-1949-3
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The pursuit of high-throughput sample analysis from complex matrix demands development of multiple ionization techniques with complementary specialties. A versatile integrated ambient ionization source (iAmIS) platform is proposed in this work, based on the idea of integrating multiple functions, enhancing the efficiency of current ionization techniques, extending the applications, and decreasing the cost of the instrument. The design of the iAmIS platform combines flowing atmospheric pressure afterglow (FAPA) source/direct analysis in real time (DART), dielectric barrier discharge ionization (DBDI)/low-temperature plasma (LTP), desorption electrospray ionization (DESI), and laser desorption (LD) technique. All individual and combined ionization modes can be easily attained by modulating parameters. In particular, the FAPA/DART&DESI mode can realize the detection of polar and nonpolar compounds at the same time with two different ionization mechanisms: proton transfer and charge transfer. The introduction of LD contributes to the mass spectrometry imaging and the surface-assisted laser desorption (SALDI) under ambient condition. Compared with other individual or multi-mode ion source, the iAmIS platform provides the flexibility of choosing different ionization modes, broadens the scope of the analyte detection, and facilitates the analysis of complex samples.
引用
收藏
页码:1408 / 1415
页数:8
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