Deleterious genetic influence of CX3CR1 genotypes on HIV-1 disease progression

被引：27

作者：

Faure, S

Meyer, L

Genin, E

Pellet, P

Debré, P

Théodorou, I

Combadière, C

机构：

[1] Hop La Pitie Salpetriere, INSERM U543, Paris, France

[2] INSERM, U569, Serv Epidemiol, Le Kremlin Bicetre, France

[3] Hop Bicetre, Fac Med, INSERM, U535, Le Kremlin Bicetre, France

来源：

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2003年 / 32卷 / 03期

关键词：

HIV; chemokine; CX3CR1; polymorphism;

D O I：

10.1097/00126334-200303010-00014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We previously reported that patients homozygous for a specific mutation (M280) in the chemokine receptor CX3CR1 progressed to AIDS more rapidly than those with other genotypes. This deleterious effect would predict that a cohort of prevalent patients would be depleted in M280 carriers, because these patients would have disappeared before recruitment. This hypothesis is confirmed ill this new Study based on the French SEROCO cohort showing that patients homozygous for the M280 allele were rare among the seroprevalent group. These results may explain the conflicting results published on the impact of CX3CR1 polymorphism in seroconverters.

引用

页码：335 / 337

页数：3

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