Synthesis of coumarin derivatives and their cytoprotective effects on t-BHP-induced oxidative damage in HepG2 cells

被引：16

作者：

Ando, Tomomi ^{[1
]}

Nagumo, Mina ^{[2
]}

Ninomiya, Masayuki ^{[1
,2
]}

Tanaka, Kaori ^{[3
,4
]}

Linhardt, Robert J. ^{[5
]}

Koketsu, Mamoru ^{[1
,2
]}

机构：

[1] Gifu Univ, Fac Engn, Dept Mat Sci & Technol, 1-1 Yanagido, Gifu 5011193, Japan

[2] Gifu Univ, Fac Engn, Dept Chem & Biomol Sci, 1-1 Yanagido, Gifu 5011193, Japan

[3] Gifu Univ, Life Sci Res Ctr, Div Anaerobe Res, 1-1 Yanagido, Gifu 5011193, Japan

[4] Gifu Univ, United Grad Sch Drug Discovery & Med Informat Sci, 1-1 Yanagido, Gifu 5011193, Japan

[5] Rensselaer Polytech Inst, Ctr Biotechnol & Interdisciplinary Studies, Troy, NY 12180 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2018年 / 28卷 / 14期

关键词：

Coumarin; Cytoprotection; Human hepatoma HepG2 cell; THERAPEUTIC AGENTS; CONSTITUENTS; PATHWAY; PLANTS; ROOTS;

D O I：

10.1016/j.bmcl.2018.06.018

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Coumarins are ubiquitous in higher plants and exhibit various biological actions. The aim of this study was to investigate the structure-activity relationships of coumarin derivatives on tert-butyl hydroperoxide (t-BHP)-induced oxidative damage in human hepatoma HepG2 cells. A series of coumarin derivatives were prepared and assessed for their cytoprotective effects. Among these, a caffeoyl acid-conjugated dihydropyranocoumarin derivative, caffeoyllomatin, efficiently protected against cell damage elicited by t-BHP. Our findings suggest that caffeoyllomatin appears to be a potent cytoprotective agent.

引用

页码：2422 / 2425

页数：4

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