Interval prediction is an efficient approach for quantifying the uncertainties of future flow. In this paper, a novel method, based on the combination of a deep residual neural network (ResNet) and lower and upper bound estimation (LUBE), is proposed to forecast future flow and construct prediction intervals. LUBE is proposed by optimizing a LUBE-based objective function and adjusting the type and quantity of residual blocks to design a combined residual network. The final proposed interval prediction model is stResNet-LUBEproposed. The performance of the stResNet-LUBEproposed model is verified using the spatiotemporal dataset of Tunxi, which is a small and medium watershed. The performance of proposed model is mainly evaluated by the root mean square error (RMSE), coefficient of determination (R-2), and coverage width-based criterion (CWC). The experimental results show that the average values of RMSE, R-2, and CWC of the proposed model are better than those of the spatiotemporal deep learning model stCNN-LUBEproposed, the deep learning model LSTM-LUBEproposed, and the machine learning model MLP-LUBEproposed by 1.881%, 10.574%, and 14.113%; 2.198%, 15.754%, and 18.546%; and 10.572%, 35.907%, and 46.819%, respectively (predict 6-step). (C) 2021 Elsevier B.V. All rights reserved.