Diagnostic Accuracy of Interleukin-27 between Tuberculous Pleural Effusion and Malignant Pleural Effusion: A Meta-Analysis

被引:37
作者
Liu, Qing
Yu, Yan-Xia
Wang, Xiao-Juan
Wang, Zheng
Wang, Zhen
机构
[1] Capital Med Univ, Beijing Inst Resp Med, Dept Resp & Crit Care Med, Beijing, Peoples R China
[2] Capital Med Univ, Beijing Chaoyang Hosp, Beijing, Peoples R China
基金
中国国家自然科学基金;
关键词
Interleukin-27; Tuberculous/malignant pleural effusion; Meta-analysis; ADENOSINE-DEAMINASE; INTERFERON-GAMMA; T-CELLS; PERFORMANCE; CD4(+); TESTS;
D O I
10.1159/000486963
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Background: The concentration assay of pleural effusion interleukin- 27 (IL-27) has raised concern for diagnosing tuberculous pleurisy. Compared with malignant pleural effusion (MPE), the concentration of IL-27 in tuberculous pleural effusion (TPE) increased significantly. Accurate differentiating diagnosis is essential for choosing treatment for pleural effusion. Objective: The present meta-analysis is aimed at determining the accuracy of IL-27 in the differential diagnosis between TPE and MPE. Material and Method: After having retrieved the published studies, we combined the sensibility (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR) of IL-27 in the diagnosis of TPE compared to MPE using a fixed-effect model. The summary receiver operating characteristic curve was applied to estimate the overall test performance. Results: In total, 550 patients (285 patients with TPE and 265 patients with MPE), included in 7 case-control studies, were enrolled. The summary assessments for IL-27 in the diagnosis between TPE and MPE were: SEN 0.93 (95% CI 0.90-0.96), SPE 0.97 (95% CI 0.94-0.98), PLR 25.88 (95% CI 13.84-48.39), NLR 0.07 (95% CI 0.05-0.11), and DOR 333.26 (95% CI 146.10-760.19), respectively. The maximal joint SEN and SPE was 0.95; the area under the curve was 0.99. Conclusion: IL-27 determination is a relatively accurate test for the diagnosis of TPE, which has very high SEN and SPE for discriminating TPE from MPE. The results of IL-27 assays should be interpreted in parallel with clinical findings and the results of conventional tests. (C) 2018 S. Karger AG, Basel
引用
收藏
页码:469 / 477
页数:9
相关论文
共 31 条
  • [1] [Anonymous], HEBEI MED J
  • [2] [Anonymous], ARCH INTERNAL MED, DOI 10.1001/archinte.150.6.1190
  • [3] [Anonymous], CHIN J ANTITUBERC
  • [4] The biology and therapeutic potential of interleukin 27
    Batten, Marcel
    Ghilardi, Nico
    [J]. JOURNAL OF MOLECULAR MEDICINE-JMM, 2007, 85 (07): : 661 - 672
  • [5] Towards complete and,accurate reporting of studies of diagnostic accuracy: the STARD initiative
    Bossuyt, PM
    Reitsma, JB
    Bruns, DE
    Gatsonis, CA
    Glasziou, PP
    Irwig, LM
    Lijmer, JG
    Moher, D
    Rennie, D
    de Vet, HCE
    [J]. BRITISH MEDICAL JOURNAL, 2003, 326 (7379): : 41 - 44
  • [6] The performance of tests of publication bias and other sample size effects in systematic reviews of diagnostic test accuracy was assessed
    Deeks, JJ
    Macaskill, P
    Irwig, L
    [J]. JOURNAL OF CLINICAL EPIDEMIOLOGY, 2005, 58 (09) : 882 - 893
  • [7] TUBERCULOUS PLEURAL EFFUSIONS
    EPSTEIN, DM
    KLINE, LR
    ALBELDA, SM
    MILLER, WT
    [J]. CHEST, 1987, 91 (01) : 106 - 109
  • [8] The diagnostic odds ratio: a single indicator of test performance
    Glas, AS
    Lijmer, JG
    Prins, MH
    Bonsel, GJ
    Bossuyt, PMM
    [J]. JOURNAL OF CLINICAL EPIDEMIOLOGY, 2003, 56 (11) : 1129 - 1135
  • [9] Potent antitumor activity of interleukin-27
    Hisada, M
    Kamiya, S
    Fujita, K
    Belladonna, ML
    Aoki, T
    Koyanagi, Y
    Mizuguchi, J
    Yoshimoto, T
    [J]. CANCER RESEARCH, 2004, 64 (03) : 1152 - 1156
  • [10] USERS GUIDES TO THE MEDICAL LITERATURE .3. HOW TO USE AN ARTICLE ABOUT A DIAGNOSTIC-TEST .B. WHAT ARE THE RESULTS AND WILL THEY HELP ME IN CARING FOR MY PATIENTS
    JAESCHKE, R
    GUYATT, GH
    SACKETT, DL
    GUYATT, G
    BASS, E
    BRILLEDWARDS, P
    BROWMAN, G
    COOK, D
    FARKOUH, M
    GERSTEIN, H
    HAYNES, B
    HAYWARD, R
    HOLBROOK, A
    JUNIPER, E
    LEE, H
    LEVINE, M
    MOYER, V
    NISHIKAWA, J
    OXMAN, A
    PATEL, A
    PHILBRICK, J
    RICHARDSON, WS
    SAUVE, S
    SACKETT, D
    SINCLAIR, J
    TROUT, KS
    TUGWELL, P
    TUNIS, S
    WALTER, S
    WILSON, M
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1994, 271 (09): : 703 - 707