iPHACE: integrative navigation in pharmacological space

被引：19

作者：

Garcia-Serna, Ricard ^{[1
,2
]}

Ursu, Oleg ^{[3
]}

Oprea, Tudor I. ^{[3
]}

Mestres, Jordi ^{[1
,2
]}

机构：

[1] Inst Municipal Invest Med, Chemogenom Lab, Res Unit Biomed Informat GRIB, E-08003 Barcelona, Catalonia, Spain

[2] Univ Pompeu Fabra, Barcelona 08003, Catalonia, Spain

[3] Univ New Mexico, Sch Med, Div Biocomp, Albuquerque, NM 87131 USA

来源：

BIOINFORMATICS | 2010年 / 26卷 / 07期

基金：

美国国家卫生研究院;

关键词：

DRUGS; NETWORKS;

D O I：

10.1093/bioinformatics/btq061

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The increasing availability of experimentally determined binding affinities for drugs on multiple protein targets requires the design of specific mining and visualization tools that graphically integrate chemical and biological data in an efficient environment. With this aim, we developed iPHACE, an integrative web-based tool to navigate in the pharmacological space defined by small molecule drugs contained in the IUPHAR-DB, with additional interactions present in PDSP. Extending beyond traditional querying and filtering tools, iPHACE offers a means to extract knowledge from the target profile of drugs as well as from the drug profile of protein targets.

引用

页码：985 / 986

页数：2

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