Inhalable gadofullerenol/[70] fullerenol as high-efficiency ROS scavengers for pulmonary fibrosis therapy

被引：36

作者：

Zhou, Yue

Zhen, Mingming ^{[1
]}

Ma, Haijun

Li, Jie

Shu, Chunying

Wang, Chunru ^{[1
]}

机构：

[1] Chinese Acad Sci, Key Lab Mol Nanostruct & Nanotechnol, CAS Res Educ Ctr Excellence Mol Sci, Beijing Natl Lab Mol Sci,Inst Chem, Beijing 100190, Peoples R China

来源：

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | 2018年 / 14卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Gadofullerenol; 70] Fullerenol; Inhalant; ROS scavenger; Pulmonary fibrosis; OXIDATIVE-INDUCED STRESS; REACTIVE OXYGEN; LUNG FIBROSIS; TGF-BETA; BLEOMYCIN; NANOPARTICLES; INFLAMMATION; RATS; MICE; PROTECTION;

D O I：

10.1016/j.nano.2018.03.008

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Pulmonary fibrosis has become a fatal disease for its high incidence and few effective drugs available in clinic. In this study, gadofullerenol (GF-OH) and [70] fullerenol (C-70-OH) nanoparticles (NPs) prepared by a one-pot reaction were designed as nanomedicines to treat this fatal disease. It was revealed that the inhalation of gadofullerenols and [70] fullerenols substantially alleviates the collagen deposition induced by acute lung injury. Based on detailed studies of oxidative stress parameters and transforming growth factor-beta(1) (TGF beta(1)), we demonstrated they owned the antioxidant and anti-inflammatory functions for the modulation of ROS-mediated inflammation process. Thus the therapeutic effect may be associated with synergistic mechanism of scavenging free radicals and indirectly modulating TGF-beta(1) expression. Moreover, GF-OH NPs were observed to show the superiority to C-70-OH NPs both in vitro and in vivo due to the structural distinction. These results suggest the inhalable fullerenols are highly potential for clinical therapy of pulmonary fibrosis. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：1361 / 1369

页数：9

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