A Versatile One-Pot Procedure for the Synthesis of 5-Aryl-6H-1,3,4-thiadiazine-2-amines from Aromatic Ketones

被引：0

作者：

Hartmann, Rafael ^{[1
]}

Malmstrom, Jonas ^{[1
]}

Sibley, Graham ^{[2
]}

Lehmann, Fredrik ^{[1
]}

机构：

[1] OnTarget Chem AB, Virdings Alle 18, SE-75450 Uppsala, Sweden

[2] F2G Ltd, Lankro Way, Manchester M3 0LX, Lancs, England

来源：

SYNLETT | 2016年 / 27卷 / 06期

关键词：

cyclization; heterocycles; carbazones; chemoselectivity; one-pot procedure; MATRIX-METALLOPROTEINASE INHIBITORS; DERIVATIVES; PROFILE;

D O I：

10.1055/s-0035-1561332

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

6H-1,3,4-Thiadiazines are a promising class of non-aromatic heterocycles for the agricultural and pharmaceutical industry. Although known for a long time, they have not received widespread attention, in part due to their cumbersome synthesis. The novel route described herein for the direct transformation of aromatic alkyl ketones into 5-aryl-6H-1,3,4-thiadiazine-2-amines provides moderate to excellent yields while employing readily available reagents under mild reaction conditions.

引用

页码：864 / 867

页数：4

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