Marital status and prostate cancer incidence: a pooled analysis of 12 case-control studies from the PRACTICAL consortium

被引：30

作者：

Salmon, Charlotte ^{[1
]}

Song, Lixin ^{[2
,3
]}

Muir, Kenneth ^{[4
,5
]}

Pashayan, Nora ^{[6
,7
]}

Dunning, Alison M. ^{[7
]}

Batra, Jyotsna ^{[8
,9
]}

Chambers, Suzanne ^{[10
]}

Stanford, Janet L. ^{[11
,12
]}

Ostrander, Elaine A. ^{[13
]}

Park, Jong Y. ^{[14
]}

Lin, Hui-Yi ^{[15
]}

Cussenot, Olivier ^{[16
]}

Cancel-Tassin, Geraldine ^{[17
]}

Menegaux, Florence ^{[18
]}

Cordina-Duverger, Emilie ^{[18
]}

Kogevinas, Manolis ^{[19
,20
,21
,22
]}

Llorca, Javier ^{[22
,23
]}

Kaneva, Radka ^{[24
]}

Slavov, Chavdar ^{[25
,26
]}

Razack, Azad ^{[27
]}

Lim, Jasmine ^{[27
]}

Gago-Dominguez, Manuela ^{[28
,29
]}

Castelao, Jose Esteban ^{[31
]}

Kote-Jarai, Zsofia ^{[30
]}

Eeles, Rosalind A. ^{[32
,33
]}

Parent, Marie-Elise ^{[1
,34
]}

机构：

[1] Univ Quebec, Inst Natl Rech Sci, Ctr Armand Frappier Sante Biotechnol, Epidemiol & Biostat Unit, 531 Boul Prairies, Laval, PQ H7V 1B7, Canada

[2] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27515 USA

[3] Univ N Carolina, Sch Nursing, Chapel Hill, NC 27515 USA

[4] Univ Manchester, Div Populat Hlth, Hlth Serv Res & Primary Care, Oxford Rd, Manchester M13 9PL, Lancs, England

[5] Univ Warwick, Warwick Med Sch, Coventry CV4 7AL, W Midlands, England

[6] UCL, Dept Appl Hlth Res, London WC1E 7HB, England

[7] Univ Cambridge, Ctr Canc Genet Epidemiol, Strangeways Lab, Dept Oncol, Worts Causeway, Cambridge CB1 8RN, England

[8] Queensland Univ Technol, Australian Prostate Canc Res Ctr Qld, Inst Hlth & Biomed Innovat, Brisbane, Qld 4059, Australia

[9] Queensland Univ Technol, Sch Biomed Sci, Brisbane, Qld 4059, Australia

[10] Translat Res Inst, Brisbane, Qld 4102, Australia

[11] Australian Catholic Univ, Fac Hlth Sci, Sydney, NSW, Australia

[12] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA

[13] Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA

[14] NIH, NHGRI, 50 South Dr,Rm 5351, Bethesda, MD 20892 USA

[15] H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, 12902 Magnolia Dr, Tampa, FL 33612 USA

[16] Louisiana State Univ, Hlth Sci Ctr, Sch Publ Hlth, New Orleans, LA 70112 USA

[17] Sorbonne Univ, Tenon Hosp, AP HP, GRC 5, 4 Rue Chine, F-75020 Paris, France

[18] Tenon Hosp, CeRePP, F-75020 Paris, France

[19] Paris Saclay Univ, Exposome & Hered Team, UVSQ, CESP,INSERM,Gustave Roussy, F-94805 Villejuif, France

[20] ISGlobal, Barcelona, Spain

[21] IMIM Hosp del Mar Med Res Inst, Barcelona, Spain

[22] Univ Pompeu Fabra, Barcelona, Spain

[23] CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain

[24] Univ Cantabria, Santander 39005, Spain

[25] Med Univ Sofia, Mol Med Ctr, Dept Med Chem & Biochem, 2 Zdrave Str, Sofia 1431, Bulgaria

[26] Med Univ Sofia, Dept Urol, Sofia 1431, Bulgaria

[27] Med Univ Sofia, Alexandrovska Univ Hosp, Sofia 1431, Bulgaria

[28] Univ Malaya, Fac Med, Dept Surg, Kuala Lumpur 50603, Malaysia

[29] Complejo Hosp Univ Santiago, Inst Invest Sanitaria Santiago Compostela IDIS, Galician Fdn Genom Med, Genom Med Grp,Serv Galego Saude,SERGAS, Santiago De Compostela 15706, Spain

[30] Univ Calif San Diego, Moores Canc Ctr, Dept Family Med & Publ Hlth, La Jolla, CA 92093 USA

[31] Complexo Hosp Univ Vigo, CHUVI Hosp, Inst Invest Biomed Galicia Sur IISGS, Genet Oncol Unit, Vigo 36204, Pontevedra, Spain

[32] Inst Canc Res, London SM2 5NG, England

[33] Royal Marsden NHS Fdn Trust, London SW3 6JJ, England

[34] Univ Montreal, Sch Publ Hlth, Montreal, PQ, Canada

来源：

EUROPEAN JOURNAL OF EPIDEMIOLOGY | 2021年 / 36卷 / 09期

基金：

加拿大健康研究院; 英国医学研究理事会;

关键词：

Marital status; Prostate cancer; Consortium; Pooled analysis; Meta-analysis; LIFE-STYLE FACTORS; SOCIAL RELATIONSHIPS; RISK-FACTORS; HEALTH; ASSOCIATION; NATIONWIDE; SURVIVAL; BEHAVIOR; GRADE; MEN;

D O I：

10.1007/s10654-021-00781-1

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

While being in a committed relationship is associated with a better prostate cancer prognosis, little is known about how marital status relates to its incidence. Social support provided by marriage/relationship could promote a healthy lifestyle and an increased healthcare seeking behavior. We investigated the association between marital status and prostate cancer risk using data from the PRACTICAL Consortium. Pooled analyses were conducted combining 12 case-control studies based on histologically-confirmed incident prostate cancers and controls with information on marital status prior to diagnosis/interview. Marital status was categorized as married/partner, separated/divorced, single, or widowed. Tumours with Gleason scores >= 8 defined high-grade cancers, and low-grade otherwise. NCI-SEER's summary stages (local, regional, distant) indicated the extent of the cancer. Logistic regression was used to derive odds ratios (ORs) and 95% confidence intervals (CI) for the association between marital status and prostate cancer risk, adjusting for potential confounders. Overall, 14,760 cases and 12,019 controls contributed to analyses. Compared to men who were married/with a partner, widowed men had an OR of 1.19 (95% CI 1.03-1.35) of prostate cancer, with little difference between low- and high-grade tumours. Risk estimates among widowers were 1.14 (95% CI 0.97-1.34) for local, 1.53 (95% CI 1.22-1.92) for regional, and 1.56 (95% CI 1.05-2.32) for distant stage tumours. Single men had elevated risks of high-grade cancers. Our findings highlight elevated risks of incident prostate cancer among widowers, more often characterized by tumours that had spread beyond the prostate at the time of diagnosis. Social support interventions and closer medical follow-up in this sub-population are warranted.

引用

页码：913 / 925

页数：13

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