Mn(II), Co(II) and Zn(II) complexes with heterocyclic substituted thiosemicarbazones: Synthesis, characterization, X-ray crystal structures and antitumor comparison

被引：142

作者：

Li, Ming Xue ^{[1
]}

Chen, Chun Ling ^{[1
]}

Zhang, Dong ^{[1
]}

Niu, Jing Yang ^{[1
]}

Ji, Bian Sheng ^{[2
]}

机构：

[1] Henan Univ, Inst Mol & Crystal Engn, Coll Chem & Chem Engn, Kaifeng 475001, Peoples R China

[2] Henan Univ, Coll Pharm, Kaifeng 475001, Peoples R China

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 07期

基金：

中国博士后科学基金;

关键词：

Thiosemicarbazone; Transition metal; Complex; Crystal structure; Cytotoxicity; VITRO ANTIBACTERIAL ACTIVITY; IN-VITRO; COPPER(II) COMPLEXES; 2-BENZOYLPYRIDINE-DERIVED THIOSEMICARBAZONES; STEROIDAL THIOSEMICARBAZONE; PALLADIUM(II) COMPLEXES; 2-ACETYLPYRIDINE; CHEMISTRY; METHYL;

D O I：

10.1016/j.ejmech.2010.04.009

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Transition metal complexes Mn(L-1)(2) (1), Mn(L-2)(2) (2), Co(L-3)(2)Cl 4H(2)O (3), Zn(L-3)(2) DMF (4), Co(HL4)(2)(ClO4)(2) 3H(2)O (5) and Zn(L-5)(2) DMF (6) where HL1 = 2-acetylpyridine thiosemicarbazone, HL2 = 2-acetylpyridine N (4)-methylthiosemicarbazone, HL3 = 2-benzoylpyricline thiosemicarbazone, HL4 = 2-benzoylpyridine N (4)-methylthiosemicarbazone and HL5 = 2-benzoylpyridine N(4)-phenylthiosemicarbazone, have been synthesized. The complexes 1, 2,5 and 6 were characterized by elemental analysis, IR spectra and single-crystal X-ray diffraction studies. Preliminary in vitro screening indicated that all the tested compounds showed significant antitumor activity against K562 leucocythemia cancer cell line. (C) 2010 Elsevier Masson SAS. All rights reserved.

引用

页码：3169 / 3177

页数：9

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