Bladder and urethral function in pelvic organ prolapsed lysyl oxidase like-1 knockout mice

被引：29

作者：

Liu, Guiming

Daneshgari, Firouz

Li, Mei

Lin, Danli

Lee, Una

Li, Tiansen

Damaser, Margot S.

机构：

[1] Cleveland Clin, Glickman Urol Inst, Cleveland, OH 44195 USA

[2] Cleveland Clin, Dept Biomed Engn, Cleveland, OH 44195 USA

[3] Louis Stokes Cleveland VA Med Ctr, Cleveland, OH USA

[4] Harvard Univ, Sch Med, Dept Ophthalmol, Massachusetts Eye & Ear Infirm, Boston, MA 02115 USA

来源：

BJU INTERNATIONAL | 2007年 / 100卷 / 02期

关键词：

urinary incontinence; pelvic organ prolapse; elastin; lysyl oxidase like-1; mice;

D O I：

10.1111/j.1464-410X.2007.06929.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

To examine bladder and urethral function in pelvic organ prolapsed lysyl oxidase like-1 (LOXL1) knockout mice. MATERIALS AND METHODS Female parous Loxl1(-/-) mice in the stable phase of prolapse, and age-matched wild type (WT) mice (six each) had conscious cystometry, leak-point pressure (LPP) testing, and contractile responses assessed of their bladder muscle strips to KCl, electrical-field stimulation, ATP, and carbachol.

引用

页码：414 / 418

页数：5

共 13 条

[1] Lower urogenital tract anatomical and functional phenotype in lysyl oxidase like-1 knockout mice resembles female pelvic floor dysfunction in humans
Lee, Una J.
Gustilo-Ashby, A. Marcus
Daneshgari, Firouz
Kuang, Mei
Vurbic, Drina
Lin, Dan Li
Flask, Chris A.
Li, Tiansen
Damaser, Margot S.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2008, 295 (02) : F545 - F555
[2] Validation of Genetically Matched Wild-Type Strain and Lysyl Oxidase-Like 1 Knockout Mouse Model of Pelvic Organ Prolapse
Couri, Bruna M.
Borazjani, Ali
Lenis, Andrew T.
Balog, Brian
Kuang, Mei
Lin, Dan Li
Damaser, Margot S.
FEMALE PELVIC MEDICINE AND RECONSTRUCTIVE SURGERY, 2014, 20 (05): : 287 - 292
[3] Changes in expression of fibulin-5 and lysyl oxidase-like 1 associated with pelvic organ prolapse
Jung, Hyun Joo
Jeon, Myung Jae
Yim, Ga Won
Kim, Sei Kwang
Choi, Jong Rak
Bai, Sang Wook
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 2009, 145 (01) : 117 - 122
[4] Decreased expression of elastin, fibulin-5 and lysyl oxidase-like 1 in the uterosacral ligaments of postmenopausal women with pelvic organ prolapse
Zhao, Bai-hui
Zhou, Jian-hong
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 2012, 38 (06) : 925 - 931
[5] Is lysyl oxidase-like protein-1, alpha-1 antitrypsin, and neutrophil elastase site specific in pelvic organ prolapse?
Man, Weng Chi
Ho, Jason Yen-Ping
Wen, Yan
Sokol, Eric R.
Polan, Mary L.
Chen, Bertha
INTERNATIONAL UROGYNECOLOGY JOURNAL, 2009, 20 (12) : 1423 - 1429
[6] Is lysyl oxidase-like protein-1, alpha-1 antitrypsin, and neutrophil elastase site specific in pelvic organ prolapse?
Weng Chi Man
Jason Yen-Ping Ho
Yan Wen
Eric R. Sokol
Mary L. Polan
Bertha Chen
International Urogynecology Journal, 2009, 20 : 1423 - 1429
[7] Altered mechanics of vaginal smooth muscle cells due to the lysyl oxidase-like1 knockout
Ferreira, J. P. S.
Kuang, M.
Parente, M. P. L.
Natal Jorge, R. M.
Wang, R.
Eppell, S. J.
Damaser, M.
ACTA BIOMATERIALIA, 2020, 110 (110) : 175 - 187
[8] Lysyl oxidase like-1 deficiency in optic nerve head astrocytes elicits reactive astrocytosis and alters functional effects of astrocyte derived exosomes
Hariani, Harsh N.
Ghosh, Anita K.
Rosen, Sasha M.
Tso, Huen-Yee
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EXPERIMENTAL EYE RESEARCH, 2024, 240
[9] Integral role for lysyl oxidase-like-1 in conventional outflow tissue function and behavior
Li, Guorong
Schmitt, Heather
Johnson, William M.
Lee, Chanyoung
Navarro, Iris
Cui, Jenny
Fleming, Todd
Gomez-Caraballo, Maria
Elliott, Michael H.
Sherwood, Joseph M.
Hauser, Michael A.
Farsiu, Sina
Ethier, C. Ross
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FASEB JOURNAL, 2020, 34 (08) : 10762 - 10777
[10] Deletion of the lysyl oxidase-like 1 gene induces impaired elastin fiber synthesis and inefficient urethral closure in rats
Kadekawa, Katsumi
Nishijima, Saori
Noguchi, Katsuhiko
Okitsu, Shiho
Karube, Kennosuke
Matsumoto, Seiji
Yamamoto, Hideyuki
Sugaya, Kimio
BIOMEDICAL RESEARCH-TOKYO, 2021, 42 (01): : 23 - 31

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