Immunoglobulin G4-related Disease Accompanied by Peripheral Neuropathy: A Report of Two Cases

被引：2

作者：

Kawazoe, Tomoya ^{[1
]}

Inoue, Tomoyuki ^{[1
]}

Tobisawa, Shinsuke ^{[1
]}

Sugaya, Keizo ^{[1
]}

Shimizu, Toshio ^{[1
]}

Miyamoto, Kazuhito ^{[1
]}

Goto, Manaka ^{[2
]}

Yokogawa, Naoto ^{[2
]}

Azuma, Sanami ^{[3
]}

Itagaki, Shingo ^{[4
]}

Nishida, Kenji ^{[5
]}

Morita, Yasuhiro ^{[6
]}

Nagao, Masahiro ^{[1
]}

Isozaki, Eiji ^{[1
]}

机构：

[1] Tokyo Metropolitan Neurol Hosp, Dept Neurol, Fuchu, Tokyo, Japan

[2] Tokyo Metropolitan Tama Med Ctr, Dept Rheumat Dis, Fuchu, Tokyo, Japan

[3] Tokyo Metropolitan Tama Med Ctr, Dept Otolaryngol Head & Neck Surg, Fuchu, Tokyo, Japan

[4] Tokyo Metropolitan Tama Med Ctr, Dept Pathol, Fuchu, Tokyo, Japan

[5] Tokyo Metropolitan Tama Med Ctr, Dept Endocrinol & Metab, Fuchu, Tokyo, Japan

[6] Tokyo Metropolitan Tama Med Ctr, Dept Surg, Fuchu, Tokyo, Japan

来源：

INTERNAL MEDICINE | 2021年 / 60卷 / 12期

基金：

日本学术振兴会;

关键词：

case report; IgG4-related disease; systemic autoimmune disease; peripheral neuropathy; vasculitic neuropathy;

D O I：

10.2169/internalmedicine.6461-20

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Due to its rarity and the limited literature, the clinicopathological characteristics of peripheral nerve involvement in immunoglobulin G4 (IgG4)-related disease are unknown. We present two cases of IgG4-related disease, accompanied by peripheral neuropathy, presenting as unilateral ptosis (case 1) and sclerosing cholangitis (case 2), respectively. In both cases, sural nerve biopsy indicated vasculitis as the underlying pathophysiology; the peripheral neuropathy was refractory to corticosteroid therapy. In contrast to the previously proposed pathomechanism of IgG4-related neuropathy (direct lymphoplasmacytic infiltration), the pathological findings in our cases suggest that vasculitis occurs secondary to systemic autoimmune conditions.

引用

页码：1941 / 1947

页数：7

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