Role of Skin Biopsies in the Diagnosis of Hemophagocytic Lymphohistiocytosis

被引：7

作者：

Santos-Arroyo, Aileen ^{[1
]}

Barrera-Llaurador, Julian ^{[2
]}

Sanchez, Julio E. ^{[1
]}

Martin-Garcia, Rafael ^{[1
]}

Sanchez, Jorge L. ^{[1
]}

机构：

[1] Univ Puerto Rico, Sch Med, Dept Dermatol, San Juan, PR 00936 USA

[2] Univ Puerto Rico, Sch Med, Transit Year Program, San Juan, PR 00936 USA

来源：

AMERICAN JOURNAL OF DERMATOPATHOLOGY | 2017年 / 39卷 / 07期

关键词：

hemophagocytosis; hemophagocytic syndrome; hemophagocytic lymphohistiocytosis; CD163; CD-163; macrophage activation syndrome; skin biopsy; MACROPHAGE ACTIVATION SYNDROME; CUTANEOUS MANIFESTATIONS; SCAVENGER RECEPTOR; PATHOGENESIS; GUIDELINES; CD163;

D O I：

10.1097/DAD.0000000000000825

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

This is a report of a 15-year-old female who presented with a skin eruption and clinical features consistent with severe sepsis and septic shock. A diagnosis of acquired hemophagocytic lymphohistiocytosis (HLH) was made and confirmed by bone marrow analysis. Skin biopsy showed hemophagocytosis and CD163-positive staining of macrophages. We briefly review the clinical, histologic, and laboratory findings of hemophagocytic lymphohistiocytosis in addition to the potential role of skin biopsies in this condition.

引用

页码：E86 / E89

页数：4

共 23 条

[1] Recent advances in the diagnosis and treatment of hemophagocytic lymphohistiocytosis
Bode, Sebastian F. N.
Lehmberg, Kai
Maul-Pavicic, Andrea
Vraetz, Thomas
Janka, Gritta
zur Stadt, Udo
Ehl, Stephan
[J]. ARTHRITIS RESEARCH & THERAPY, 2012, 14 (03)
[2] Performance of Current Guidelines for Diagnosis of Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis
Davi, Sergio
Minoia, Francesca
Pistorio, Angela
Horne, AnnaCarin
Consolaro, Alessandro
Rosina, Silvia
Bovis, Francesca
Cimaz, Rolando
Gamir, Maria Luz
Ilowite, Norman T.
Kone-Paut, Isabelle
Feitosa de Oliveira, Sheila Knupp
McCurdy, Deborah
Silva, Clovis Artur
Sztajnbok, Flavio
Tsitsami, Elena
Unsal, Erbil
Weiss, Jennifer E.
Wulffraat, Nico
Abinun, Mario
Aggarwal, Amita
Apaz, Maria Teresa
Astigarraga, Itziar
Corona, Fabrizia
Cuttica, Ruben
D'Angelo, Gianfranco
Eisenstein, Eli M.
Hashad, Soad
Lepore, Loredana
Mulaosmanovic, Velma
Nielsen, Susan
Prahalad, Sampath
Rigante, Donato
Stanevicha, Valda
Sterba, Gary
Susic, Gordana
Takei, Syuji
Trauzeddel, Ralf
Zletni, Mabruka
Ruperto, Nicolino
Martini, Alberto
Cron, Randy Q.
Ravelli, Angelo
[J]. ARTHRITIS & RHEUMATOLOGY, 2014, 66 (10) : 2871 - 2880
[3] Frequency, clinical features and prognosis of cutaneous manifestations in adult patients with reactive haemophagocytic syndrome
Fardet, L.
Galicier, L.
Vignon-Pennamen, M. -D.
Regnier, S.
Noguera, M. E.
de Labarthe, A.
Raffoux, E.
Martinez, V.
Buyse, S.
Viguier, M.
Osio, A.
Lebbe, C.
Morel, P.
Dupuy, A.
Rybojad, M.
[J]. BRITISH JOURNAL OF DERMATOLOGY, 2010, 162 (03) : 547 - 553
[4] FAVARA BE, 1992, SEMIN DIAGN PATHOL, V9, P63
[5] Hemophagocytic lymphohistiocytosis: review of etiologies and management
George, Melissa R.
[J]. JOURNAL OF BLOOD MEDICINE, 2014, 5 : 69 - 86
[6] Macrophage activation syndrome and reactive hemophagocytic lymphohistiocytosis: the same entities?
Grom, AA
[J]. CURRENT OPINION IN RHEUMATOLOGY, 2003, 15 (05) : 587 - 590
[7] Macrophage activation syndrome: advances towards understanding pathogenesis
Grom, Alexei A.
Mellins, Elizabeth D.
[J]. CURRENT OPINION IN RHEUMATOLOGY, 2010, 22 (05) : 561 - 566
[8] HENTER JI, 1991, SEMIN ONCOL, V18, P29
[9] How I treat hemophagocytic lymphohistiocytosis
Jordan, Michael B.
Allen, Carl E.
Weitzman, Sheila
Filipovich, Alexandra H.
McClain, Kenneth L.
[J]. BLOOD, 2011, 118 (15) : 4041 - 4052
[10] Hemophagocytosis in Cutaneous Autoimmune Disease
Kerl, Katrin
Wolf, Ingrid H.
Cerroni, Lorenzo
Wolf, Peter
French, Lars E.
Kerl, Helmut
[J]. AMERICAN JOURNAL OF DERMATOPATHOLOGY, 2015, 37 (07) : 539 - 543

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