Role of Skin Biopsies in the Diagnosis of Hemophagocytic Lymphohistiocytosis

被引：7
作者：
Santos-Arroyo, Aileen [1 ]
Barrera-Llaurador, Julian [2 ]
Sanchez, Julio E. [1 ]
Martin-Garcia, Rafael [1 ]
Sanchez, Jorge L. [1 ]
机构：
[1] Univ Puerto Rico, Sch Med, Dept Dermatol, San Juan, PR 00936 USA
[2] Univ Puerto Rico, Sch Med, Transit Year Program, San Juan, PR 00936 USA
来源：
AMERICAN JOURNAL OF DERMATOPATHOLOGY | 2017年 / 39卷 / 07期
关键词：
hemophagocytosis; hemophagocytic syndrome; hemophagocytic lymphohistiocytosis; CD163; CD-163; macrophage activation syndrome; skin biopsy; MACROPHAGE ACTIVATION SYNDROME; CUTANEOUS MANIFESTATIONS; SCAVENGER RECEPTOR; PATHOGENESIS; GUIDELINES; CD163;
D O I：
10.1097/DAD.0000000000000825
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
This is a report of a 15-year-old female who presented with a skin eruption and clinical features consistent with severe sepsis and septic shock. A diagnosis of acquired hemophagocytic lymphohistiocytosis (HLH) was made and confirmed by bone marrow analysis. Skin biopsy showed hemophagocytosis and CD163-positive staining of macrophages. We briefly review the clinical, histologic, and laboratory findings of hemophagocytic lymphohistiocytosis in addition to the potential role of skin biopsies in this condition.
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页码：E86 / E89
页数：4
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