Implications of Fibroblast growth factor/Klotho system in glucose metabolism and diabetes

被引：35

作者：

Donate-Correa, Javier ^{[1
]}

Martin-Nunez, Ernesto ^{[1
]}

Perez Delgado, Nayra ^{[2
]}

Muros de Fuentes, Mercedes ^{[2
]}

Ortiz Arduan, Alberto ^{[3
,4
,5
]}

Mora-Fernandez, Carmen ^{[1
]}

Navarro Gonzalez, Juan F. ^{[1
,6
]}

机构：

[1] Univ Hosp Nuestra Senora de Candelaria, Res Unit, Carretera Rosario 145, Santa Cruz De Tenerife 38010, Spain

[2] Univ Hosp Nuestra Senora de Candelaria, Clin Anal Serv, Santa Cruz De Tenerife 38010, Spain

[3] Univ Autonoma Madrid, Sch Med, IIS Fdn Jimenez Diaz, Fdn Renal Inigo Alvarez Toledo IRSIN, Madrid, Spain

[4] REDinREN, Madrid, Spain

[5] Fdn Jimenez Diaz, Dept Nephrol, E-28040 Madrid, Spain

[6] Univ Hosp Nuestra Senora de Candelaria, Serv Nephrol, REDinREN, Santa Cruz De Tenerife 38010, Spain

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2016年 / 28卷

关键词：

Diabetes; Fibroblast growth factors; Glucose metabolism; Klotho; INCREASES ENERGY-EXPENDITURE; ACTIVATED-RECEPTOR-GAMMA; BETA-KLOTHO EXPRESSION; ANTIAGING GENE KLOTHO; FATTY LIVER-DISEASE; SERUM FGF21 LEVELS; INSULIN SENSITIVITY; PPAR-GAMMA; ANTIDIABETIC ACTIONS; CHINESE SUBJECTS;

D O I：

10.1016/j.cytogfr.2015.12.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Diabetes mellitus, especially type 2 diabetes, remains the dominant metabolic disease worldwide, with an expected increase in prevalence of over 50% in the next 20 years. Our knowledge about the pathophysiology of type 2 diabetes continues to be incomplete, with unmet medical need for new therapies. The characterization of the fibroblast growth factor (FGF) family and the discovery of endocrine FGFs provided new information on the mechanisms of regulation and homeostasis of carbohydrate metabolism. More specifically, FGF19 and FGF21 signaling pathways have been linked to different glucose metabolic processes, including hepatic glucose synthesis, glycogen synthesis, glucose uptake, and insulin sensitivity, among others, and these molecules have been further related to the pathophysiology of diabetes mellitus. In-depth comprehension of these growth factors may bring to light new potential therapeutic targets for the treatment of diabetes mellitus. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：71 / 77

页数：7

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