The Effect of Routine Therapy Alone and Combined with Hyperbaric Oxygen Treatment on Prognostic Factors in Dogs with Acute Pancreatitis

The aim of this study was to evaluate the effect of supportive treatment combined with hyperbaric oxygen (HBO) therapy in dogs with acute pancreatitis by prognostic factors. Dogs entering the trial were randomly assigned to receive only regular supportive therapy (control group) or combined hyperbaric oxygen therapy with symptomatic and supportive therapy (HBOT group). The regular supportive measurements consisted of intravenous fluid, analgesia, antibiotics, antiemetics, gastric acid suppression, nutritional management, and so on. If the patient had diabetes mellitus, hyperglycemia was controlled by insulin. The dogs of the HBOT group were conducted in hyperbaric animal chamber (PAHI-A, Pan-America Hyperbarics Inc., R.O.C.) and HBO therapy involved 90 min of 100% oxygen treatment at a pressure of 2.5 ATA, once to twice daily for a total of 3 to 5 sessions. There were significant findings regarding to specific canine pancreatic lipase immunoreactivity (Spec cPL) and C-reactive protein (CRP) in the survivors, but no significant differences were found in the non-survivors. The down trend of sequential CRP concentration was noticed in HBOT group. The level of creatinine may be as an important criterion when the patients with AP were first visit clinic. The prognostic factors such as CRP, Spec cPL had a good response to routine combined with HBOT in survivors group. Likewise, the level of Spec cPL was decreased significantly after treatment no matter routine or routine combined with HBOT in survivors group. HBOT combined with symptomatic and routine treatment might improve systemic inflammation probably in canine acute pancreatitis. In survivors group the creatinine levels was significant lower than that in non-survivors group. Therefore, the levels of creatinine can be as prognostic factor in dogs with acute pancreatitis. (C)2019 PVJ. All rights reserved