Levodopa motor complications in Parkinson's disease

被引:349
作者
Obeso, JA [1 ]
Olanow, CW
Nutt, JG
机构
[1] Clin Univ & Med Sch, Movement Disorders & Basal Ganglia Grp, Dept Neurol & Neurosurg, Ctr Neurosci, Pamplona 31080, Spain
[2] CUNY Mt Sinai Sch Med, Dept Neurol, New York, NY 10029 USA
[3] Oregon Hlth & Sci Univ, Dept Neurol, Portland, OR 97201 USA
关键词
D O I
10.1016/S1471-1931(00)00031-8
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Parkinson's disease (PD) is an age-related neurodegenerative disorder with an average onset age of 60 years. In the United States, approximately one million persons suffer from PD, and there are 60 000 newly diagnosed cases every year. The estimated cost of PD to society is $27 billion per year. Based on United States Census Bureau projections, it is estimated that the frequency of PD will increase fourfold by the year 2040, making it an even larger burden on patients, their families and society.
引用
收藏
页码:S2 / S7
页数:6
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共 69 条
[1]  
BARBEAU A, 1971, LANCET, V1, P395
[2]   CHRONIC TREATMENT WITH L-DOPA, BUT NOT BROMOCRIPTINE INDUCES DYSKINESIA IN MPTP-PARKINSONIAN MONKEYS - CORRELATION WITH [H-3] SPIPERONE BINDING [J].
BEDARD, PJ ;
DIPAOLO, T ;
FALARDEAU, P ;
BOUCHER, R .
BRAIN RESEARCH, 1986, 379 (02) :294-299
[3]  
Bejjani BP, 2000, ANN NEUROL, V47, P655, DOI 10.1002/1531-8249(200005)47:5<655::AID-ANA16>3.0.CO
[4]  
2-#
[5]  
Benabid AL, 2000, PROG NEUROL SURG, V15, P196
[6]   WEARING-OFF FLUCTUATIONS IN PARKINSONS-DISEASE - CONTRIBUTION OF POSTSYNAPTIC MECHANISMS [J].
BRAVI, D ;
MOURADIAN, MM ;
ROBERTS, JW ;
DAVIS, TL ;
SOHN, YH ;
CHASE, TN .
ANNALS OF NEUROLOGY, 1994, 36 (01) :27-31
[7]   The early diagnosis of Parkinson's disease [J].
Brooks, DJ .
ANNALS OF NEUROLOGY, 1998, 44 (03) :S10-S18
[8]  
Brotchie JM, 2000, ANN NEUROL, V47, pS105
[9]   The corticostriatal projection: From synaptic plasticity to dysfunctions of the basal ganglia [J].
Calabresi, P ;
Pisani, A ;
Mercuri, NB ;
Bernardi, G .
TRENDS IN NEUROSCIENCES, 1996, 19 (01) :19-24
[10]  
Calon F, 2000, ANN NEUROL, V47, pS70