Wound healing in cutaneous leishmaniasis: A double edged sword of IL-10 and TGF-β

被引：47
作者：
Abdoli, Amir [1 ]
Maspi, Nahid [1 ]
Ghaffarifar, Fatemeh [1 ]
机构：
[1] Tarbiat Modares Univ, Dept Parasitol, Fac Med Sci, Tehran, Iran
来源：
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES | 2017年 / 51卷
关键词：
Wound healing; Leishmania; Cutaneous leishmaniasis; IL-10; TGF-beta; GROWTH-FACTOR-BETA; REGULATORY T-CELLS; MAJOR INFECTION; KALA-AZAR; INTERLEUKIN-10; PRODUCTION; ALTERNATIVE ACTIVATION; INFLAMMATORY RESPONSE; ANTIGEN PRESENTATION; DISEASE PROGRESSION; INTERFERON-GAMMA;
D O I：
10.1016/j.cimid.2017.02.001
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Immune responses have a crucial role during the wound healing process in cutaneous leishmaniasis (CL). However, there are several paradoxes in immunity against CL. On the one hand, regulatory cytokines interleukin (IL)-10 and transforming growth factor beta (TGF-beta) increase susceptibility to CL through suppression of several proinflammatory cytokines that require for defense against CL. On the other hand, these cytokines play a pivotal role in the acceleration of wound healing process. This review discusses about the dual role of IL-10 and TGF-beta during the wound healing process and immunity against CL to offer a new insight about wound healing in CL. (C) 2017 Elsevier Ltd. All rights reserved.
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收藏
页码：15 / 26
页数：12
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