Endothelial dysfunction in acute and long standing COVID-19: A prospective cohort study

被引：88

作者：

Oikonomou, Evangelos ^{[1
,2
]}

Souvaliotis, Nektarios ^{[1
]}

Lampsas, Stamatios ^{[1
]}

Siasos, Gerasimos ^{[1
,2
]}

Poulakou, Garyphallia ^{[3
]}

Theofilis, Panagiotis ^{[2
]}

Papaioannou, Theodore G. ^{[2
]}

Haidich, Anna-Bettina ^{[4
]}

Tsaousi, Georgia ^{[5
,6
]}

Ntousopoulos, Vasileios ^{[3
]}

Sakka, Vissaria ^{[3
]}

Charalambous, Georgios ^{[7
]}

Rapti, Vasiliki ^{[3
]}

Raftopoulou, Sylvia ^{[8
]}

Syrigos, Konstantinos ^{[3
]}

Tsioufis, Costas ^{[2
]}

Tousoulis, Dimitris ^{[2
]}

Vavuranakis, Manolis ^{[1
]}

机构：

[1] Natl & Kapodistrian Univ Athens, Dept Cardiol 3, Med Sch, Sotiria Chest Dis Hosp, Athens, Greece

[2] Natl & Kapodistrian Univ Athens, Dept Cardiol 1, Med Sch, Hippokration Gen Hosp, Athens, Greece

[3] Natl & Kapodistrian Univ Athens, Dept Med 3, Sotiria Chest Dis Hosp, Med Sch, Athens, Greece

[4] Aristotle Univ Thessaloniki, Dept Hyg Social Prevent Med & Med Stat, Med Sch, Thessaloniki, Greece

[5] Aristotle Univ Thessaloniki, Med Sch, Dept Anesthesiol, Thessaloniki, Greece

[6] Aristotle Univ Thessaloniki, Med Sch, ICU, Thessaloniki, Greece

[7] Hippokrateion Hosp, Emergency Dept, Athens, Greece

[8] Sotiria Chest Dis Hosp, Intens Care Unit, Athens, Greece

来源：

VASCULAR PHARMACOLOGY | 2022年 / 144卷

关键词：

COVID-19; Flow-mediated dilation; Endothelial function; Endothelium; CELL INFECTION;

D O I：

10.1016/j.vph.2022.106975

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Background: Coronavirus disease-19 (COVID-19) is implicated by active endotheliitis, and cardiovascular morbidity. The long-COVID-19 syndrome implications in atherosclerosis have not been elucidated yet. We assessed the immediate, intermediate, and long-term effects of COVID-19 on endothelial function.& nbsp;Methods: In this prospective cohort study, patients hospitalized for COVID-19 at the medical ward or Intensive Care Unit (ICU) were enrolled and followed up to 6 months post-hospital discharge. Medical history and labo-ratory examinations were performed while the endothelial function was assessed by brachial artery flow-mediated dilation (FMD). Comparison with propensity score-matched cohort (control group) was performed at the acute (upon hospital admission) and follow-up (1 and 6 months) stages.& nbsp;Results: Seventy-three patients diagnosed with COVID-19 (37% admitted in ICU) were recruited. FMD was significantly (p < 0.001) impaired in the COVID-19 group (1.65 +/- 2.31%) compared to the control (6.51 +/- 2.91%). ICU-treated subjects presented significantly impaired (p = 0.001) FMD (0.48 +/- 1.01%) compared to those treated in the medical ward (2.33 +/- 2.57%). During hospitalization, FMD was inversely associated with Interleukin-6 and Troponin I (p < 0.05 for all). Although, a significant improvement in FMD was noted during the follow-up (acute: 1.75 +/- 2.19% vs. 1 month: 4.23 +/- 2.02%, vs. 6 months: 5.24 +/- 1.62%; p = 0.001), FMD remained impaired compared to control (6.48 +/- 3.08%) at 1 month (p < 0.001) and 6 months (p = 0.01) post-hospital discharge.& nbsp;Conclusion: COVID-19 patients develop a notable endothelial dysfunction, which is progressively improved over a 6-month follow-up but remains impaired compared to healthy controls subjects. Whether chronic dysregulation of endothelial function following COVID-19 could be accompanied by a residual risk for cardiovascular and thrombotic events merits further research.

引用

页数：7

共 40 条

[1]

Ambrosino P., BIOMEDICINES, V9

[2] Clinical Assessment of Endothelial Function in Convalescent COVID-19 Patients Undergoing Multidisciplinary Pulmonary Rehabilitation [J].

Ambrosino, Pasquale ;

Molino, Antonio ;

Calcaterra, Ilenia ;

Formisano, Roberto ;

Stufano, Silvia ;

Spedicato, Giorgio Alfredo ;

Motta, Andrea ;

Papa, Antimo ;

Di Minno, Matteo Nicola Dario ;

Maniscalco, Mauro .

BIOMEDICINES, 2021, 9 (06)

[3]

[Anonymous], 2021, Obesity

[4] Interleukin 6 Inhibition and Coronary Artery Disease in a High-Risk Population: A Prospective Community-Based Clinical Study [J].

Bacchiega, Bruno Cesar ;

Bacchiega, Ana Beatriz ;

Gomez Usnayo, Magali Justina ;

Bedirian, Ricardo ;

Singh, Gurkirpal ;

Castelar Pinheiro, Geraldo da Rocha .

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2017, 6 (03)

[5] Low Brachial Artery Flow-Mediated Dilation Predicts Worse Prognosis in Hospitalized Patients with COVID-19 [J].

Bianconi, Vanessa ;

Mannarino, Massimo Raffaele ;

Figorilli, Filippo ;

Schiaroli, Elisabetta ;

Cosentini, Elena ;

Batori, Giuseppe ;

Marini, Ettore ;

Sahebkar, Amirhossein ;

Grignani, Francesco ;

Gidari, Anna ;

Francisci, Daniela ;

Pirro, Matteo .

JOURNAL OF CLINICAL MEDICINE, 2021, 10 (22)

[6] Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19 [J].

Bonaventura, Aldo ;

Vecchie, Alessandra ;

Dagna, Lorenzo ;

Martinod, Kimberly ;

Dixon, Dave L. ;

Van Tassell, Benjamin W. ;

Dentali, Francesco ;

Montecucco, Fabrizio ;

Massberg, Steffen ;

Levi, Marcel ;

Abbate, Antonio .

NATURE REVIEWS IMMUNOLOGY, 2021, 21 (05) :319-329

[7] Cardiovascular disease and COVID-19: a consensus paper from the ESC Working Group on Coronary Pathophysiology & Microcirculation, ESC Working Group on Thrombosis and the Association for Acute CardioVascular Care (ACVC), in collaboration with the European Heart Rhythm Association (EHRA) [J].

Cenko, Edina ;

Badimon, Lina ;

Bugiardini, Raffaele ;

Claeys, Marc J. ;

De Luca, Giuseppe ;

de Wit, Cor ;

Derumeaux, Genevieve ;

Dorobantu, Maria ;

Duncker, Dirk J. ;

Eringa, Etto C. ;

Gorog, Diana A. ;

Hassager, Christian ;

Heinzel, Frank R. ;

Huber, Kurt ;

Manfrini, Olivia ;

Milicic, Davor ;

Oikonomou, Evangelos ;

Padro, Teresa ;

Trifunovic-Zamaklar, Danijela ;

Vasiljevic-Pokrajcic, Zorana ;

Vavlukis, Marija ;

Vilahur, Gemma ;

Tousoulis, Dimitris .

CARDIOVASCULAR RESEARCH, 2021, 117 (14) :2705-2729

[8]

COVID-19, THER TRIAL SYN 2020

[9] Histopathological observations in COVID-19: a systematic review [J].

Deshmukh, Vishwajit ;

Motwani, Rohini ;

Kumar, Ashutosh ;

Kumari, Chiman ;

Raza, Khursheed .

JOURNAL OF CLINICAL PATHOLOGY, 2021, 74 (02) :76-83

[10]

Diaz J.V., 2021, LANCET INFECT DIS

← 1 2 3 4 →