Analytical and semipreparative separation of the enantiomers of new acetylcholinesterase inhibitors by high-performance liquid chromatography

被引：2
作者：
Del Giudice, MR
Ferretti, R
La Torre, F
Mosca, A
Volpe, MT
Zanitti, L
机构：
[1] Ist Super Sanita, Lab Chim Farm, I-00161 Rome, Italy
[2] Ist Super Sanita, Farmacol Lab, I-00161 Rome, Italy
来源：
CHROMATOGRAPHIA | 2003年 / 57卷 / 5-6期
关键词：
column liquid chromatography; enantiomer separation; semipreparative enantiomer separation; acetylcholinesterase inhibitors;
D O I：
10.1007/BF02492399
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The resolution of the enantiomers of new acetylcholinesterase inhibitors by high-performance liquid chromatography (HPLC) was investigated on stationary phases containing cellulose tris(3,5 methylphenylcarbomide) (Chiralcel OD). The effects of the mobile phase on retention, enantioselectivity and resolution were also studied. Ethanol and isopropanol were tested as organic modifiers and the influence of diethylamine was investigated. The effect of temperature on chiral separations was also studieded.
引用
收藏
页码：293 / 299
页数：7
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