Increased Prevalence of Severe Fever with Thrombocytopenia Syndrome in Eastern China Clustered with Multiple Genotypes and Reasserted Virus during 2010-2015

被引：49

作者：

Li, Zhifeng ^{[1
,2
]}

Hu, Jianli ^{[1
]}

Cui, Lunbiao ^{[1
]}

Hong, Ye ^{[2
]}

Liu, Jianwei ^{[3
]}

Li, Pengfei ^{[9
]}

Guo, Xiling ^{[1
]}

Liu, Wendong ^{[1
]}

Wang, Xiaochen ^{[1
]}

Qi, Xian ^{[1
]}

Wu, Bin ^{[1
]}

Feng, Zhi ^{[4
]}

Shen, Aihua ^{[5
]}

Liu, Xuejian ^{[6
]}

Zhao, Hongjun ^{[6
]}

Tan, Wenwen ^{[7
]}

Zhou, Jiangang ^{[7
]}

Xing, Zheng ^{[2
,8
]}

Bao, Changjun ^{[1
]}

机构：

[1] Jiangsu Prov Ctr Dis Prevent & Control, Nanjing, Jiangsu, Peoples R China

[2] Nanjing Univ, Med Sch, Nanjing, Jiangsu, Peoples R China

[3] Shandong Univ, Sch Publ Hlth, Jinan, Shandong, Peoples R China

[4] Jiangning Ctr Dis Prevent & Control, Jiangning, Peoples R China

[5] Lishui Ctr Dis Prevent & Control, Lishui, Peoples R China

[6] Xuyi Ctr Dis Prevent & Control, Xuyi, Peoples R China

[7] Yixing Ctr Dis Prevent & Control, Yixing, Peoples R China

[8] Univ Minnesota Twin Cities, Coll Vet Med, St Paul, MN USA

[9] Nanjing Univ TCM, Affiliated Hosp, Jiangsu Prov Hosp TCM, Clin Lab, Nanjing, Jiangsu, Peoples R China

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

关键词：

EPIDEMIOLOGIC FEATURES; SOUTH-KOREA; SFTS VIRUS; BUNYAVIRUS; ANIMALS; TICKS;

D O I：

10.1038/s41598-017-06853-1

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Severe fever with thrombocytopenia syndrome (SFTS) is a novel tick-borne viral disease with high mortality. Since January 2010, we have conducted an epidemiological surveillance and etiological study of SFTS in Jiangsu and Anhui provinces. From January 2010 through December 2015, a total of 286 SFTS cases were confirmed in Jiangsu and Anhui provinces with a case fatality rate of 16.1%. The majority of confirmed SFTS cases were distributed in the border area of Jiangsu and Anhui provinces. Our findings suggest that the SFTS prevalence rate rose since 2010 and reached its highest in 2015. Phylogenetic analysis demonstrated that the majority of the SFTSV strains (83.6%) from Jiangsu and Anhui provinces belonged to genotypes A and D. Notably, we identified three strains of SFTSV clustered into the genotype E. This is the first report of the genotype E SFTSV strains in mainland of China. A reassortment between genotype A and D was found in the central region of the endemic areas, where three SFTSV genotypes (A, C and D) were co-circulating.

引用

页数：9

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