A solvent-free synthesis of 1,2,4,5-tetrasubstituted imidazoles using molecular iodine as catalyst

被引：23

作者：

Ren, Yi-Ming ^{[1
]}

Cai, Chun ^{[2
]}

机构：

[1] Anhui Univ Technol & Sci, Dept Biochem Engn, Wuhu 241000, Peoples R China

[2] Nanjing Univ Sci & Technol, Chem Engn Coll, Nanjing 210094, Peoples R China

来源：

JOURNAL OF CHEMICAL RESEARCH | 2010年 / 03期

关键词：

molecular iodine; 1,2,4,5-tetrasubstituted imidazoles; solvent-free; ONE-POT SYNTHESIS; TETRASUBSTITUTED IMIDAZOLES; MICROWAVE IRRADIATION; CARBONYL-COMPOUNDS; HIGHLY EFFICIENT; 2-IMIDAZOLINES; DERIVATIVES; ALDEHYDES; ALCOHOLS; ACID;

D O I：

10.3184/030823410X12659021476402

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient method for the synthesis of 1,2,4,5-tetrasubstituted imidazoles by three-component condensation of benzil, benzonitrile derivatives and primary amines under solvent-free conditions using molecular iodine as catalyst is described with high product yields. The significant features of the iodine-catalysed condensation are operational simplicity, inexpensive reagents, high yield of products and use of non-toxic reagents.

引用

页码：133 / 134

页数：2

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