Renal cell carcinoma (RCC): fatter is better? A review on the role of obesity in RCC

被引：30

作者：

Turco, Fabio ^{[1
]}

Tucci, Marcello ^{[2
]}

Di Stefano, Rosario Francesco ^{[1
]}

Samuelly, Alessandro ^{[1
]}

Bungaro, Maristella ^{[1
]}

Audisio, Marco ^{[1
]}

Pisano, Chiara ^{[1
]}

Di Maio, Massimo ^{[3
]}

Scagliotti, Giorgio Vittorio ^{[1
]}

Buttigliero, Consuelo ^{[1
]}

机构：

[1] Univ Turin, San Luigi Gonzaga Hosp, Dept Oncol, Div Med Oncol, Turin, Italy

[2] Cardinal Massaia Hosp, Med Oncol Dept, Asti, Italy

[3] Univ Turin, Ordine Mauriziano Hosp, Dept Oncol, Div Med Oncol, Turin, Italy

来源：

关键词：

renal cell carcinoma; obesity; obesity paradox; tyrosine kinase inhibitors; immune checkpoint inhibitors; BODY-MASS INDEX; ACID SYNTHASE; VISCERAL OBESITY; CANCER; MORTALITY; ASSOCIATION; SURVIVAL; PROGNOSIS; METAANALYSIS; METASTASIS;

D O I：

10.1530/ERC-20-0457

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Obesity represents a well-known risk factor for renal cell carcinoma development. Several studies evaluated the relationship between obesity and outcome in patients with non-metastatic and metastatic renal cell carcinoma using different parameters such as BMI, visceral fat area and s.c. fat area. These studies suggest that obesity is associated with a better prognosis in renal cell carcinoma patients. This phenomenon is called obesity paradox and it was found in other diseases in which obesity rep resents an established risk factor such as heart failure, diabetes, atrial fibrillation, hypertension and coronary heart disease. The purpose of this review is to analyze the mec hanisms by which obesity increases the risk of renal cell carcinoma development, to describe the evidence available to date about the link obesity-outcome and to evaluate the mech anisms to explain this apparently paradoxical relationship.

引用

页码：R207 / R216

页数：10

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