Does aneuploidy per se cause developmental abnormalities?

被引：9
作者：
Ford, JH [1 ]
机构：
[1] GCAT Pty Ltd, Port Adelaide, SA 5011, Australia
来源：
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 1997年 / 396卷 / 1-2期
关键词：
D O I：
10.1016/S0027-5107(97)00184-X
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The following questions are addressed: (A) What are aneuploidogens and how do they act? (B) Is there any evidence that aneuploidy per se causes malformations? (C) What examples are there of abnormalities, apparently attributable to aneuploidogens acting as teratogens? (D) Do abnormalities of cell division cause both teratogenesis and aneuploidy? Considerable research has addressed question (A), but there is little which addresses the other three questions. The question of whether aneuploidy per se causes malformations remains open. Some suggestions for further research are made. (C) 1997 Elsevier Science B.V.
引用
收藏
页码：195 / 203
页数：9
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