Itraconazole Treatment of Nonmeningeal Coccidioidomycosis in Children Two Case Reports and Review of the Literature

被引：12
作者：
Homans, James D. [1 ]
Spencer, LaShonda [1 ]
机构：
[1] Univ So Calif, Div Infect Dis, Dept Pediat, Sch Med, Los Angeles, CA 90033 USA
来源：
PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2010年 / 29卷 / 01期
关键词：
itraconazole; coccidioidomycosis; pulmonary; skeletal; children; ORAL SOLUTION; MENINGITIS; PHARMACOKINETICS; FLUCONAZOLE; VORICONAZOLE; THERAPY;
D O I：
10.1097/INF.0b013e3181b20ebd
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Coccidioides immitis causes a wide range of disease in humans. Fluconazole and itraconazole are effective treatments. Clinical evidence suggests that itraconazole is equivalent or superior to fluconazole in treating osteoarticular infections in rates of cure and recurrence. We report 2 cases of coccidioidomycosis involving bone in children successfully treated with itraconazole oral solution. Itraconazole oral solution is effective in treating nonmeningeal coccidioidomycosis in children, particularly skeletal disease, and infections that are refractory to fluconazole.
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收藏
页码：65 / 67
页数：3
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