Phospholamban and cardiac contractile function

被引：131

作者：

Brittsan, AG ^{[1
]}

Kranias, EG ^{[1
]}

机构：

[1] Univ Cincinnati, Coll Med, Dept Pharmacol & Cell Biophys, Cincinnati, OH 45267 USA

来源：

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 2000年 / 32卷 / 12期

关键词：

phospholamban; sarcoplasmic reticulum; cardiac contractility; beta-adrenergic stimulation;

D O I：

10.1006/jmcc.2000.1270

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

PLB is a major regulator of cardiac contractile kinetics through its ability to modulate SERCA2 function, and thus SR Ca2+ load. Significant advancements have been made in understanding the dynamics of PLB's interaction with SERCA2, which affect cardiac SR function and contractility. Such progress has paved the way for the development of therapeutic strategies, involving inhibition of PLB expression or activity, which may be valuable in the treatment of defective Ca2+ homeostasis in various cardiomyopathies.

引用

页码：2131 / 2139

页数：9

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