Can memory be improved?: A discussion on the role of ras, GABA, acetylcholine, NO, insulin, TNF-α, and long-chain polyunsaturated fatty acids in memory formation and consolidation

被引:47
作者
Das, UN [1 ]
机构
[1] EFA Sci LLC, Norwood, MA 02062 USA
关键词
polyunsaturated fatty acids; memory; learning;
D O I
10.1016/S0387-7604(02)00221-8
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
It is proposed that long-chain polyunsaturated fatty acids when given from the perinatal period will ensure proper development and growth of the brain and maintain the activity and/or concentrations of ras, nitric oxide, insulin, and various neurotransmitters and cytokines at physiological level and thus, improve memory and prevent learning deficits. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:251 / 261
页数:11
相关论文
共 88 条
  • [1] NEURODEVELOPMENTAL QUOTIENT OF HEALTHY TERM INFANTS AT 4 MONTHS AND FEEDING PRACTICE - THE ROLE OF LONG-CHAIN POLYUNSATURATED FATTY-ACIDS
    AGOSTONI, C
    TROJAN, S
    BELLU, R
    GIOVANNINI, M
    [J]. PEDIATRIC RESEARCH, 1995, 38 (02) : 262 - 266
  • [2] Nitric oxide acts directly in the presynaptic neuron to produce long-term potentiation in cultured hippocampal neurons
    Arancio, O
    Kiebler, M
    Lee, CJ
    LevRam, V
    Tsien, RY
    Kandel, ER
    Hawkins, RD
    [J]. CELL, 1996, 87 (06) : 1025 - 1035
  • [3] Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways
    Arbiser, JL
    Moses, MA
    Fernandez, CA
    Ghiso, N
    Cao, YH
    Klauber, N
    Frank, D
    Brownlee, M
    Flynn, E
    Parangi, S
    Byers, HR
    Folkman, J
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (03) : 861 - 866
  • [4] Neurobiology - No-new-neurons dogma loses ground
    Barinaga, M
    [J]. SCIENCE, 1998, 279 (5359) : 2041 - 2042
  • [5] LY294002, an inhibitor of phosphoinositide 3-kinase given into rat hippocampus impairs acquisition, consolidation and retrieval of memory for one-trial step-down inhibitory avoidance
    Barros, DM
    Souza, TME
    de Souza, MM
    Choi, H
    Silva, TDE
    Lenz, G
    Medina, JH
    Izquierdo, I
    [J]. BEHAVIOURAL PHARMACOLOGY, 2001, 12 (08): : 629 - 634
  • [6] Control of synaptic strength by glial TNFα
    Beattie, EC
    Stellwagen, D
    Morishita, W
    Bresnahan, JC
    Ha, BK
    Von Zastrow, M
    Beattie, MS
    Malenka, RC
    [J]. SCIENCE, 2002, 295 (5563) : 2282 - 2285
  • [7] Involvement of hippocampal cAMP/cAMP-dependent protein kinase signaling pathways in a late memory consolidation phase of aversively motivated learning in rats
    Bernabeu, R
    Bevilaqua, L
    Ardenghi, P
    Bromberg, E
    Schmitz, P
    Bianchin, M
    Izquierdo, I
    Medina, JH
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (13) : 7041 - 7046
  • [8] Further evidence for the involvement of a hippocampal cGMP/cGMP-dependent protein kinase cascade in memory consolidation
    Bernabeu, R
    Schroder, N
    Quevedo, J
    Cammarota, M
    Izquierdo, I
    Medina, JH
    [J]. NEUROREPORT, 1997, 8 (9-10) : 2221 - 2224
  • [9] MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network
    Bhalla, US
    Ram, PT
    Iyengar, R
    [J]. SCIENCE, 2002, 297 (5583) : 1018 - 1023
  • [10] Emergent properties of networks of biological signaling pathways
    Bhalla, US
    Iyengar, R
    [J]. SCIENCE, 1999, 283 (5400) : 381 - 387