Apoptosis-inducing activity of lipid derivatives of gallic acid

被引：0
作者：
Saeki, K
Yuo, A
Isemura, M
Abe, I
Seki, T
Noguchi, H
机构：
[1] Univ Shizuoka, Sch Pharmaceut Sci, Shizuoka 4228526, Japan
[2] Univ Shizuoka, Sch Food & Nutr Sci, Shizuoka 4228526, Japan
[3] Int Med Ctr Japan, Res Inst, Dept Hematol, Shinjuku Ku, Tokyo 1628655, Japan
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2000年 / 23卷 / 11期
关键词：
gallic acid; lipid; apoptosis; farnesol; U937; cell;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Gallic acid derivatives with a lipophilic group (hydrogenated farnesyl gallate, lauryl gallate, gallic acid laurylamide and cholesteryl gallate) were examined for their ability to induce apoptosis in human monoblastic leukemia U937 cells. Farnesyl ester derivative is the most potent apoptosis inducer among the compounds examined, The results suggest that lipid derivatives can augment the apoptosis-inducing activity of gallic acid depending on the structure. These findings will provide useful information in developing anti-cancer agents.
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收藏
页码：1391 / 1394
页数：4
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