Are epigenetic drugs for diabetes and obesity at our door step?

被引：46

作者：

Arguelles, Andrix O. ^{[1
]}

Meruvu, Sunitha ^{[1
]}

Bowman, John D. ^{[2
]}

Choudhury, Mahua ^{[1
]}

机构：

[1] Texas A&M Hlth Sci Ctr, Dept Pharmaceut Sci, Irma Lerma Rangel Coll Pharm, Kingsville, TX USA

[2] Texas A&M Hlth Sci Ctr, Dept Pharm Practice, Irma Lerma Rangel Coll Pharm, Kingsville, TX USA

来源：

DRUG DISCOVERY TODAY | 2016年 / 21卷 / 03期

关键词：

ENDOPLASMIC-RETICULUM STRESS; PROTEIN ARGININE METHYLTRANSFERASES; GLUCOSE-HOMEOSTASIS; DNA METHYLATION; ADIPOSE-TISSUE; VALPROIC ACID; INSULIN SENSITIVITY; OXIDATIVE STRESS; GENE-EXPRESSION; MOUSE MODEL;

D O I：

10.1016/j.drudis.2015.12.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Recent interest in epigenetics has focused on small molecules aimed at modifying disease-specific gene expression, including diabetes and obesity. Several major classes of epigenetic modifier include drugs already in the marketplace as well as several in various stages of study. These classes include histone deacetylase inhibitors (HDACi), histone acetyltransferase inhibitors (HATi), protein arginine methyltransferase inhibitors (PRMTis), DNA methyltransferase inhibitors (DNMTis), histone demethylating inhibitors (HDMis), and sirtuin-activating compounds (STACs). In this review, we discuss drugs with epigenetic properties that have been identified as potential therapeutic agents in the treatment of diabetes and obesity, including those currently in clinical trials.

引用

页码：499 / 509

页数：11

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