Functional Gold Nanoparticles as Potent Antimicrobial Agents against Multi-Drug-Resistant Bacteria

被引：586

作者：

Li, Xiaoning ^{[1
]}

Robinson, Sandra M. ^{[2
]}

Gupta, Akash ^{[1
]}

Saha, Krishnendu ^{[1
]}

Jiang, Ziwen ^{[1
]}

Moyano, Daniel F. ^{[1
]}

Sahar, Ali ^{[1
]}

Riley, Margaret A. ^{[2
]}

Rotello, Vincent M. ^{[2
]}

机构：

[1] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA

[2] Univ Massachusetts, Dept Biol, Amherst, MA 01003 USA

来源：

ACS NANO | 2014年 / 8卷 / 10期

关键词：

MDR E. coli; MRSA; uropathogens; antimicrobial agents; gold nanoparticles; structure-activity relationship; mode of action; STAPHYLOCOCCUS-AUREUS; ANTIBACTERIAL; ANTIBIOTICS; INHIBITION; VANCOMYCIN; GROWTH;

D O I：

10.1021/nn5042625

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We present the use of functionalized gold nanoparticles (AuNPs) to combat multi-drug-resistant pathogenic bacteria. Tuning of the functional groups on the nanoparticle surface provided gold nanoparticles that were effective against both Gram-negative and Gram-positive uropathogens, including multi-drug-resistant pathogens. These AuNPs exhibited low toxicity to mammalian cells, and bacterial resistance was not observed after 20 generations. A strong structure-activity relationship was observed as a function of AuNP functionality, providing guidance to activity prediction and rational design of effective antimicrobial nanoparticles.

引用

收藏

页码：10682 / 10686

页数：5

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