Dibutyltin perfluoroalkanecarboxylates: synthesis, NMR characterization and in vitro antitumour activity

被引：87

作者：

Kemmer, M

Dalil, H

Biesemans, M

Martins, JC

Mahieu, B

Horn, E

de Vos, D

Tiekink, ERT

Willem, R

Gielen, M

机构：

[1] Free Univ Brussels, Fac Sci, B-1050 Brussels, Belgium

[2] Free Univ Brussels, Fac Sci Appl, Dept Gen & Organ Chem, B-1050 Brussels, Belgium

[3] Free Univ Brussels, High Resolut NMR Ctr, B-1050 Brussels, Belgium

[4] Catholic Univ Louvain, CPMC, B-1348 Louvain, Belgium

[5] Univ Tsukuba, Dept Chem, Tsukuba, Ibaraki 305, Japan

[6] Pharmachem BV, PCH Nederland, Dept Med, NL-2003 RN Haarlem, Netherlands

[7] Univ Adelaide, Dept Chem, Adelaide, SA 5005, Australia

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2000年 / 608卷 / 1-2期

基金：

澳大利亚研究理事会;

关键词：

dibutyltin perfluoroalkanecarboxylates; NMR; antitumour activity;

D O I：

10.1016/S0022-328X(00)00367-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Three dibutyltin perfluoroalkanecarboxylates have been synthesized, characterized by H-1-, C-13-, F-19- and Sn-117-NMR, Mossbauer, IR and mass spectroscopy. The structure of tetra-n-butylbis(trifluoroacetato)distannoxane has been elucidated by X-ray crystallography. The in vitro antitumour activity of the three compounds against seven human tumour cell lines was found to be as high as or even higher than that for reference compounds used clinically. (C) 2000 Published by Elsevier Science S.A.

引用

页码：63 / 70

页数：8

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