Human Mesenchymal Stem Cells in Cancer Therapy

被引:2
作者
Kalkan, R. [1 ]
Serakinci, N. [1 ]
机构
[1] Near East Univ, Dept Med Genet, Fac Med, CY-99138 Nicosia, Turkish Republi, Cyprus
来源
CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION | 2016年 / 26卷 / 01期
关键词
mesenchymal stem cells; cancer therapy; therapy; HUMAN BONE-MARROW; PROMOTING MIGRATION; PROGENITOR CELLS; STROMAL CELLS; CORD BLOOD; EXPRESSION; DELIVERY; TISSUE; DIFFERENTIATION; TRANSPLANTATION;
D O I
10.1615/CritRevEukaryotGeneExpr.v26.i1.50
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Human mesenchymal stem cells (hMSCs) have the ability to differentiate into several tissue types. Their use in cancer therapeutics or as therapeutic delivery vehicles has significant potential, particularly in their exosome/microvesicle-mediated tissue regeneration abilities. In this review, the potential use of hMSCs in cancer therapy is discussed.
引用
收藏
页码:41 / 48
页数:8
相关论文
共 74 条
[1]   Use of transcriptional regulatory sequences of telomerase (hTER and hTERT) for selective killing of cancer cells [J].
Abdul-Ghani, R ;
Ohana, P ;
Matouk, I ;
Ayesh, S ;
Ayesh, B ;
Laster, M ;
Bibi, O ;
Giladi, H ;
Molnar-Kimber, K ;
Sughayer, MA ;
de Groot, N ;
Hochberg, A .
MOLECULAR THERAPY, 2000, 2 (06) :539-544
[2]   Stem and progenitor cell-mediated tumor selective gene therapy [J].
Aboody, K. S. ;
Najbauer, J. ;
Danks, M. K. .
GENE THERAPY, 2008, 15 (10) :739-752
[3]   Tumor microenvironment: Bone marrow-mesenchymal stem cells as key players [J].
Barcellos-de-Souza, Pedro ;
Gori, Valentina ;
Bambi, Franco ;
Chiarugi, Paola .
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2013, 1836 (02) :321-335
[4]   Activation of CD74 inhibits migration of human mesenchymal stem cells [J].
Barrilleaux, Bonnie L. ;
Fischer-Valuck, Benjamin W. ;
Gilliam, Jennifer K. ;
Phinney, Donald G. ;
O'Connor, Kim C. .
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 2010, 46 (06) :566-572
[5]   Tissue distribution and engraftment of human mesenchymal stem cells immortalized by human telomerase reverse transcriptase gene [J].
Bentzon, JF ;
Stenderup, K ;
Hansen, FD ;
Schroder, HD ;
Abdallah, BM ;
Jensen, TG ;
Kassem, M .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 330 (03) :633-640
[6]  
Bhang SH, 2012, TISSUE ENG PT A, V18, P2138, DOI [10.1089/ten.TEA.2011.0640, 10.1089/ten.tea.2011.0640]
[7]   Properties of a telomerase-specific Cre/Lox switch for transcriptionally targeted cancer gene therapy [J].
Bilsland, AE ;
Fletcher-Monaghan, A ;
Keith, WN .
NEOPLASIA, 2005, 7 (11) :1020-1029
[8]   Constitutive Expression of Human Telomerase Enhances the Proliferation Potential of Human Mesenchymal Stem Cells [J].
Bischoff, David S. ;
Makhijani, Nalini S. ;
Yamaguchi, Dean T. .
BIORESEARCH OPEN ACCESS, 2012, 1 (06) :273-279
[9]   Signalling, cell cycle and pluripotency in embryonic stem cells [J].
Burdon, T ;
Smith, A ;
Savatier, P .
TRENDS IN CELL BIOLOGY, 2002, 12 (09) :432-438
[10]   Priming mesenchymal stem cells boosts stem cell therapy to treat myocardial infarction [J].
Carvalho, Juliana L. ;
Braga, Vinicius B. A. ;
Melo, Marcos B. ;
Campos, Ana Carolina D. A. ;
Oliveira, Maira S. ;
Gomes, Dawidson A. ;
Ferreira, Anderson J. ;
Santos, Robson A. S. ;
Goes, Alfredo M. .
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2013, 17 (05) :617-625