Synthesis, Spectroscopic Characterization and Biological Evaluation of Ni(II), Cu(II) and Zn(II) Complexes of Diphenyldithiocarbamate

被引：22
|
作者：
Khan, S. A. [1 ]
Ahmad, W. [1 ]
Munawar, K. S. [1 ]
Kanwal, Sadia [2 ]
机构：
[1] Univ Management & Technol, Dept Chem, Lahore 54000, Pakistan
[2] Univ Agr Faisalabad, Dept Biochem, Faisalabad 38000, Pakistan
来源：
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2018年 / 80卷 / 03期
关键词：
Diphenyldithiocarbamate (DPDTC); spectroscopic studies; antioxidant; antibacterial; antifungal activities; CHARGE-TRANSFER PHOTOCHEMISTRY; DOPED ZNO NANOPARTICLES; OXIDE NANOPARTICLES; ABUTILON-INDICUM; METAL-COMPLEXES; GREEN SYNTHESIS; ANTIBACTERIAL; ANTIOXIDANT; ANTIFUNGAL;
D O I：
10.4172/pharmaceutical-sciences.1000381
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Ni(II), Cu(II) and Zn(II) complexes of diphenyldithiocarbamate have been synthesized with the aim of developing antioxidants, potential antibacterial and antifungal agents. Synthesized metal complexes were characterized by magnetic susceptibility, elemental analysis; conductivity measurements, mass spectra, infrared, ultra violet/visible and nuclear magnetic resonance verified the chemical composition of products. Magnetic susceptibility and spectroscopic studies suggested the predicted geometry of the diphenyldithiocarbamate complexes as octahedral geometry of Ni(II) complex distortion square-planer geometry distorted towards tetrahedral for Cu(II) and Zn(II) complexes. Synthesized metal complexes exhibited remarkable antioxidant potential as compared to standard. Zn(II) complex of diphenyldithiocarbamate exhibited IC50 of 31.45 +/- 0.31 mu M while the standard, butylated hydroxytoluene exhibited IC50 of 44.67 +/- 0.45 mu M antioxidant activity. Synthesized metal complexes showed very good antibacterial and antifungal potential against Rhodococcuss, Actinomyces viscosus, Bacillus subtilis, Escherichia coli and the fungi, Aspergillus niger, Aspergillus flavus, Candida and Acetomyceta. It's concluded that synthesized metal complexes showed better antioxidant, antibacterial and antifungal potential as compared to diphenyldithiocarbamate as well as the standard and might turn out to be a valuable treatment of numerous kinds of diseases.
引用
收藏
页码：480 / 488
页数：9
相关论文
共 50 条
  • [31] Synthesis of Azo Schiff Base Ligands and Their Ni(II), Cu(II) and Zn(II) Metal Complexes as Highly-Active Antibacterial Agents
    Kasare, Mangesh S.
    Dhavan, Pratik P.
    Jadhav, Bhaskar L.
    Pawar, Suresh D.
    CHEMISTRYSELECT, 2019, 4 (36): : 10792 - 10797
  • [32] Synthesis, spectral characterization and biological evaluation of Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) complexes with thiosemicarbazone ending by pyrazole and pyridyl rings
    Yousef, T. A.
    Abu El-Reash, G. M.
    Al-Jahdali, M.
    El-Rakhawy, El-Bastawesy R.
    SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2014, 129 : 163 - 172
  • [33] Co(II) and Ni(II) Complexes of a Heterocyclic Ligand: Synthesis, Characterization, Docking and Biological Activity
    Jain, Pallavi
    Vishvakarma, Vijay K.
    Singh, Prashant
    Chandra, Sulekh
    Kumar, Dinesh
    Misra, Namita
    IRANIAN JOURNAL OF SCIENCE AND TECHNOLOGY TRANSACTION A-SCIENCE, 2022, 46 (03): : 793 - 805
  • [34] Synthesis, spectroscopic, in vitro, in silico, and in vivo studies of binuclear Cu (II), Ni (II), Ru (II), and Zn (II) complexes with tetradentate Schiff base ligand
    Marimuthu, Bhuvaneswari
    Michael, Samuel
    Jeyaraman, Porkodi
    Arulanandam, Xavier
    APPLIED ORGANOMETALLIC CHEMISTRY, 2022, 36 (06)
  • [35] Co(II) and Ni(II) Complexes of a Heterocyclic Ligand: Synthesis, Characterization, Docking and Biological Activity
    Pallavi Jain
    Vijay K. Vishvakarma
    Prashant Singh
    Sulekh Chandra
    Dinesh Kumar
    Namita Misra
    Iranian Journal of Science and Technology, Transactions A: Science, 2022, 46 : 793 - 805
  • [36] Synthesis, spectroscopic and biological activity evaluation of Ni(II), Cu(II) and Zn(II) complexes of schiff base derived from pyridoxal and 4-fluorobenzohydrazide
    Kavitha, R.
    Reddy, Ch Venkata Ramana
    Sireesha, B.
    NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2021, 40 (08) : 845 - 866
  • [37] Synthesis, characterization, DNA binding, antibacterial, antidiabetic, molecular docking and DFT studies of Ni(II), Cu(II) and Zn(II) complexes derived from heterocyclic schiff base
    Shanty, Angamaly Antony
    Mohanan, Puzhavoorparambil Velayudhan
    INORGANIC AND NANO-METAL CHEMISTRY, 2023, 53 (12) : 1380 - 1395
  • [38] DNA cleavage and antimicrobial investigation of Co(II), Ni(II), and Cu(II) complexes with triazole Schiff bases: synthesis and spectral characterization
    Kulkarni, Ajaykumar D.
    Patil, Sangamesh A.
    Naik, Vinod H.
    Badami, Prema S.
    MEDICINAL CHEMISTRY RESEARCH, 2011, 20 (03) : 346 - 354
  • [39] Synthesis, spectral characterization, and antimicrobial evaluation of new imine derived from 3-methylthiophene-2-carboxaldehyde and its Co(II), Ni(II), Cu(II), and Zn(II) metal complexes
    Singh, Kiran
    Turk, Prerna
    Dhanda, Anita
    APPLIED ORGANOMETALLIC CHEMISTRY, 2021, 35 (04)
  • [40] Synthesis and characterization of Cu(II), Co(II) and Ni(II) complexes of a benzohydrazone derivative: Spectroscopic, DFT, antipathogenic and DNA binding studies
    Okagu, Ogadimma D.
    Ugwu, Kenneth C.
    Ibeji, Collins U.
    Ekennia, Anthony C.
    Okpareke, Obinna C.
    Ezeorah, Chigozie J.
    Anarado, Chigozie J. O.
    Babahan, Ilknur
    Coban, Burak
    Yildiz, Ufuk
    Comert, Fusun
    Ujam, Oguejiofo T.
    JOURNAL OF MOLECULAR STRUCTURE, 2019, 1183 : 107 - 117
12345