Synthesis, Spectroscopic Characterization and Biological Evaluation of Ni(II), Cu(II) and Zn(II) Complexes of Diphenyldithiocarbamate

被引：22
|
作者：
Khan, S. A. [1 ]
Ahmad, W. [1 ]
Munawar, K. S. [1 ]
Kanwal, Sadia [2 ]
机构：
[1] Univ Management & Technol, Dept Chem, Lahore 54000, Pakistan
[2] Univ Agr Faisalabad, Dept Biochem, Faisalabad 38000, Pakistan
来源：
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2018年 / 80卷 / 03期
关键词：
Diphenyldithiocarbamate (DPDTC); spectroscopic studies; antioxidant; antibacterial; antifungal activities; CHARGE-TRANSFER PHOTOCHEMISTRY; DOPED ZNO NANOPARTICLES; OXIDE NANOPARTICLES; ABUTILON-INDICUM; METAL-COMPLEXES; GREEN SYNTHESIS; ANTIBACTERIAL; ANTIOXIDANT; ANTIFUNGAL;
D O I：
10.4172/pharmaceutical-sciences.1000381
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Ni(II), Cu(II) and Zn(II) complexes of diphenyldithiocarbamate have been synthesized with the aim of developing antioxidants, potential antibacterial and antifungal agents. Synthesized metal complexes were characterized by magnetic susceptibility, elemental analysis; conductivity measurements, mass spectra, infrared, ultra violet/visible and nuclear magnetic resonance verified the chemical composition of products. Magnetic susceptibility and spectroscopic studies suggested the predicted geometry of the diphenyldithiocarbamate complexes as octahedral geometry of Ni(II) complex distortion square-planer geometry distorted towards tetrahedral for Cu(II) and Zn(II) complexes. Synthesized metal complexes exhibited remarkable antioxidant potential as compared to standard. Zn(II) complex of diphenyldithiocarbamate exhibited IC50 of 31.45 +/- 0.31 mu M while the standard, butylated hydroxytoluene exhibited IC50 of 44.67 +/- 0.45 mu M antioxidant activity. Synthesized metal complexes showed very good antibacterial and antifungal potential against Rhodococcuss, Actinomyces viscosus, Bacillus subtilis, Escherichia coli and the fungi, Aspergillus niger, Aspergillus flavus, Candida and Acetomyceta. It's concluded that synthesized metal complexes showed better antioxidant, antibacterial and antifungal potential as compared to diphenyldithiocarbamate as well as the standard and might turn out to be a valuable treatment of numerous kinds of diseases.
引用
收藏
页码：480 / 488
页数：9
相关论文
共 50 条
  • [11] Synthesis, spectroscopic characterization and biological activities of N4O2 Schiff base ligand and its metal complexes of Co(II), Ni(II), Cu(II) and Zn(II)
    Al-Resayes, Saud I.
    Shakir, Mohammad
    Abbasi, Ambreen
    Amin, Kr. Mohammad Yusuf
    Lateef, Abdul
    SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2012, 93 : 86 - 94
  • [12] Synthesis, characterization, biological activity of binuclear Co(II), Cu(II) and mononuclear Ni(II) complexes of bulky multi-dentate thiosemicarbazide
    El-Gammal, O. A.
    Al-Gader, I. M. Abd
    El-Asmy, A. A.
    SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2014, 128 : 759 - 772
  • [13] Synthesis and spectroscopic characterization of Zn(II), Cd(II), and Hg(II) ciprofloxacin complexes
    Salman, Mahmoud
    Refat, Moamen S.
    El-Korashy, Sabry A.
    Hussien, Mostafa A.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2014, 84 (09) : 1841 - 1846
  • [14] Synthesis, characterization, molecular docking and DNA binding studies of Cu(II), Ni(II), Zn(II) and Mn(II) complexes
    Hassan, N.
    El-Sonbati, A. Z.
    El-Desouky, M. G.
    JOURNAL OF MOLECULAR LIQUIDS, 2017, 242 : 293 - 307
  • [15] SYNTHESIS, SPECTROSCOPIC, THERMAL, BIOLOGICAL ACTIVITIES STUDIES FOR Ni(II),Cu(II) AND Zn(II) COMPLEXES WITH PHTHALOHYDRAZIDE DERIVED LIGAND AND EVALUATION AS ANTIOXIDANTS
    Al-Ameer, Aseel H. Abad
    Shaalan, Naser
    BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA, 2025, 39 (06) : 1109 - 1118
  • [16] Synthesis, Characterization, Antimicrobial and Antiproliferative Activity Evaluation of Cu(II), Co(II), Zn(II), Ni(II) and Pt(II) Complexes with Isoniazid-Derived Compound
    Pahontu, Elena
    Ilies, Diana-Carolina
    Shova, Sergiu
    Oprean, Camelia
    Paunescu, Virgil
    Olaru, Octavian Tudorel
    Radulescu, Flavian Stefan
    Gulea, Aurelian
    Rosu, Tudor
    Draganescu, Doina
    MOLECULES, 2017, 22 (04):
  • [17] Mn(II), Co(II), Ni(II) and Cu(II) Complexes of a Tertraaza Macrocyclic Ligand: Synthesis, Characterization and Biological Screening
    Chandra, S.
    Tyagi, M.
    Sharma, K.
    JOURNAL OF THE IRANIAN CHEMICAL SOCIETY, 2009, 6 (02) : 310 - 316
  • [18] Synthesis, structural, spectroscopic, biological and catalytic activity of Co(II), Ni(II) and Cu(II) complexes of benzilic hydrazide (BH)
    El-Ghamry, Hoda
    El-Sharkawy, Rehab
    Gaber, Mohamed
    JOURNAL OF THE IRANIAN CHEMICAL SOCIETY, 2014, 11 (02) : 379 - 389
  • [19] Synthesis, spectroscopic characterization, biological screening and in vitro cytotoxic studies of 4-methyl-3-thiosemicarbazone derived Schiff bases and their Co (II), Ni (II), Cu (II) and Zn (II) complexes
    Devi, J.
    Yadav, M.
    Jindal, D. K.
    Kumar, D.
    Poornachandra, Y.
    APPLIED ORGANOMETALLIC CHEMISTRY, 2019, 33 (10)
  • [20] Synthesis, spectral, thermal, magnetic and biological characterization of Co(II), Ni(II), Cu(II) and Zn(II) complexes with a Schiff base bearing a 1,2,4-triazole pharmacophore
    Calu, Larisa
    Badea, Mihaela
    Chifiriuc, Mariana Carmen
    Bleotu, Coralia
    David, Gabriela-Iulia
    Ionita, Gabriela
    Marutescu, Luminita
    Lazar, Veronica
    Stanica, Nicolae
    Soponaru, Irina
    Marinescu, Dana
    Olar, Rodica
    JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 2015, 120 (01) : 375 - 386
12345