Von Willebrand's disease in the German shepherd dog

被引：0

作者：

Lobetti, RG ^{[1
]}

Dippenaar, T ^{[1
]}

机构：

[1] Univ Pretoria, Fac Vet Sci, Dept Compan Anim Med, ZA-0110 Onderstepoort, South Africa

来源：

JOURNAL OF THE SOUTH AFRICAN VETERINARY ASSOCIATION-TYDSKRIF VAN DIE SUID-AFRIKAANSE VETERINERE VERENIGING | 2000年 / 71卷 / 02期

关键词：

factor VIII; German shepherd dogs; haemorrhagic tendency; Von Willebrand's disease; Von Willebrand's factor assay;

D O I：

暂无

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Two litters of German shepherd dogs were evaluated for a haemorrhagic tendency that was characterised by excessive bleeding from the umbilicus at birth, haemorrhage and haematoma:formation at vaccination, excessive bruising, and lameness due to haemarthrosis. Platelet counts, clotting times and Von Willebrand's factor (VWF) assays were assessed in all dogs. Factor VIII determination was performed in 1 puppy and its parents. Based on the dotting times and VWF assay, 6 puppies (4 male and 2 female) showed type I Von Willebrand's disease (VWD), 5 (4 male and 1 female) possible type II VWD, and 4 were unaffected. One puppy with possible type II VWD had very low factor VIII activity; its sire had a normal factor activity, whereas the dam was in the low-normal range. This article reports type I and possible type II VWD in 2 related litters of German shepherd dogs, the latter being rare in German shepherd dogs.

引用

页码：118 / 121

页数：4

共 17 条

[1]

Brooks M, 1996, J AM VET MED ASSOC, V209, P926

[2]

Brooks M, 1996, J AM VET MED ASSOC, V209, P930

[3]

BROOKS M, 1992, J AM VET MED ASSOC, V200, P1123

[4]

DODDS WJ, 1984, MOD VET PRACT, V65, P681

[5]

Johnson G. S., 1987, Veterinary Clinical Pathology, V16, P7

[6] CANINE VONWILLEBRANDS DISEASE - A HETEROGENEOUS GROUP OF BLEEDING DISORDERS [J].

JOHNSON, GS ;

TURRENTINE, MA ;

KRAUS, KH .

VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE, 1988, 18 (01) :195-229

[7]

JOHNSON GS, 1980, J AM VET MED ASSOC, V176, P1261

[8]

JOHNSTONE IB, 1993, CAN VET J, V34, P679

[9]

MEYERS KM, 1992, COMP CONT EDUC PRACT, V14, P13

[10]

Moser J, 1996, J AM VET MED ASSOC, V209, P1103

← 1 2 →