TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity

被引：388

作者：

Baccala, Roberto ^{[1
]}

Hoebe, Kasper ^{[1
]}

Kono, Dwight H. ^{[1
]}

Beutler, Bruce ^{[1
]}

Theofilopoulos, Argyrios N. ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Immunol, La Jolla, CA 93037 USA

来源：

NATURE MEDICINE | 2007年 / 13卷 / 05期

关键词：

D O I：

10.1038/nm1590

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We formulate a two-phase paradigm of autoimmunity associated with systemic lupus erythematosus, the archetypal autoimmune disease. The initial Toll-like receptor (TLR)-independent phase is mediated by dendritic cell uptake of apoptotic cell debris and associated nucleic acids, whereas the subsequent TLR-dependent phase serves an amplification function and is mediated by uptake of TLR ligands derived from self-antigens (principally nucleic acids) complexed with autoantibodies. Both phases depend on elaboration of type I interferons (IFNs), and therapeutic interruption of induction or activity of these cytokines in predisposed individuals might have a substantial mitigating effect in lupus and other autoimmune diseases.

引用

页码：543 / 551

页数：9

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