Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion

被引：149
作者：
Critchley, DR [1 ]
机构：
[1] Univ Leicester, Dept Biochem, Leicester LE1 7RH, Leics, England
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2004年 / 32卷
关键词：
cytoskeleton; focal adhesions; integrin; talin; vinculin;
D O I：
10.1042/BST0320831
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The cytoskeletal proteins talin and vinculin form part of a macromolecular complex on the cytoplasmic face of integrin-mediated cellular junctions with the extracellular matrix. Recent genetic, biochemical and structural data show that talin is essential for the assembly of such junctions, whereas vinculin appears to be important in regulating adhesion dynamics and cell migration.
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收藏
页码：831 / 836
页数：6
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