Immunogenicity of autologous immunoglobulins:: Principles and practices

被引：11

作者：

Lopez-Requena, Alejandro ^{[1
]}

De Acosta, Cristina Mateo ^{[1
]}

Vazquez, Ana Maria ^{[1
]}

Perez, Rolando ^{[1
]}

机构：

[1] Ctr Mol Immunol, Dept Antibody Engn, Havana 11600, Cuba

来源：

MOLECULAR IMMUNOLOGY | 2007年 / 44卷 / 11期

关键词：

idiotype; autoimmunogenicity; anti-idiotypic antibodies; autologous immunoglobulins;

D O I：

10.1016/j.molimm.2007.01.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The immunogenicity of immunoglobulin idiotypes in syngeneic systems is a rather rare phenomenon. Very few studies have attempted to determine the mechanisms underlying the anti-idiotypic response that certain autologous idiotypes can elicit. Furthermore, the studies addressing a possible physiological role for such behaviors are even less. In the present article, the results of the characterization of a highly immunogenic idiotype are reviewed and compared with some related works on the subject. We finally propose a possible immunoregulatory role for idiotypic immunogenicity. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：3076 / 3082

页数：7

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