ANALGESIC EFFECTS OF TRANSCUTANEOUS ULTRASOUND NERVE STIMULATION IN A RAT MODEL OF OXALIPLATIN-INDUCED MECHANICAL HYPERALGESIA AND COLD ALLODYNIA

被引：6
作者：
Hsieh, Yueh-Ling [1 ]
Chen, Han-Yu [2 ]
Yang, Ching-Hsiang [1 ]
Yang, Chen-Chia [3 ]
机构：
[1] China Med Univ, Grad Inst Rehabil Sci, Dept Phys Therapy, Taichung, Taiwan
[2] Hung Kuang Univ, Dept Phys Therapy, Taichung, Taiwan
[3] Kao An Phys Med & Rehabil Clin, Taichung, Taiwan
来源：
ULTRASOUND IN MEDICINE AND BIOLOGY | 2017年 / 43卷 / 07期
关键词：
Therapeutic ultrasound; Oxaliplatin-induced peripheral neuropathy; Mechanical hyperalgesia; Cold allodynia; Substance P; Transient receptor potential channels; PAINFUL PERIPHERAL NEUROPATHY; NITRIC-OXIDE SYNTHASE; THERAPEUTIC ULTRASOUND; FOCUSED ULTRASOUND; COLORECTAL-CANCER; SCIATIC-NERVE; SUBSTANCE-P; RECEPTOR; CHEMOTHERAPY; EXPRESSION;
D O I：
10.1016/j.ultrasmedbio.2017.03.002
中图分类号：
O42 [声学];
学科分类号：
070206 ; 082403 ;
摘要：
This study investigated the effects and underlying mechanisms of therapeutic ultrasound (TUS) in a rat model of oxaliplatin-induced peripheral neuropathy. Animals received a total of eight injections with oxaliplatin (4 mg/kg), administered at 3-d intervals. TUS intervention (1 MHz, 0.5 W/cm(2)) started on the fifth oxaliplatin administration and continued for 10 consecutive d. Sensory behavioral examinations, protein levels of transient receptor potential channels (TRPM8 and TRPV1) in dorsal root ganglia (DRG) and substance P (SP) in spinal dorsal horn were examined. Results indicated that TUS can reduce mechanical and cold hyper-responsive behaviors caused by repeated administration of oxaliplatin. Oxaliplatin-related increases in protein levels of TRPM8 in DRG and SP in the dorsal horn were also reduced after TUS. Taken together, the results revealed beneficial effects of TUS on oxaliplatin-induced mechanical hyperalgesia and cold allodynia and suggested involvement of TUS biochemicals in suppressing TRPM8 in DRG and SP in spinal cords. (E-mail: sherrie@mail.cmu.edu.tw) (C) 2017 World Federation for Ultrasound in Medicine & Biology.
引用
收藏
页码：1466 / 1475
页数：10
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