STITCH 2: an interaction network database for small molecules and proteins

被引：211

作者：

Kuhn, Michael ^{[3
]}

Szklarczyk, Damian ^{[4
]}

Franceschini, Andrea ^{[5
,6
]}

Campillos, Monica ^{[1
]}

von Mering, Christian ^{[5
,6
]}

Jensen, Lars Juhl ^{[4
]}

Beyer, Andreas ^{[3
]}

Bork, Peer ^{[1
,2
]}

机构：

[1] European Mol Biol Lab, D-69117 Heidelberg, Germany

[2] Max Delbruck Ctr Mol Med, D-13092 Berlin, Germany

[3] Tech Univ Dresden, Ctr Biotechnol, D-01062 Dresden, Germany

[4] Univ Copenhagen, Fac Hlth Sci, Novo Nordisk Fdn Ctr Prot Res, DK-2200 Copenhagen, Denmark

[5] Univ Zurich, Inst Mol Biol, CH-8006 Zurich, Switzerland

[6] Univ Zurich, Swiss Inst Bioinformat, CH-8006 Zurich, Switzerland

来源：

NUCLEIC ACIDS RESEARCH | 2010年 / 38卷

关键词：

CHEMICAL BIOLOGY; TARGET; KNOWLEDGEBASE;

D O I：

10.1093/nar/gkp937

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Over the last years, the publicly available knowledge on interactions between small molecules and proteins has been steadily increasing. To create a network of interactions, STITCH aims to integrate the data dispersed over the literature and various databases of biological pathways, drug-target relationships and binding affinities. In STITCH 2, the number of relevant interactions is increased by incorporation of BindingDB, PharmGKB and the Comparative Toxicogenomics Database. The resulting network can be explored interactively or used as the basis for large-scale analyses. To facilitate links to other chemical databases, we adopt InChIKeys that allow identification of chemicals with a short, checksum-like string. STITCH 2.0 connects proteins from 630 organisms to over 74 000 different chemicals, including 2200 drugs. STITCH can be accessed at http://stitch.embl.de/.

引用

页码：D552 / D556

页数：5

共 24 条

[1] The Protein Data Bank [J].