KI-mediated radical multi-functionalization of vinyl azides: a one-pot and efficient approach to β-keto sulfones and α-halo-β-keto sulfones

被引：67

作者：

Chen, Wenteng ^{[1
]}

Liu, Xingyu ^{[1
]}

Chen, En ^{[1
]}

Chen, Binhui ^{[1
]}

Shao, Jiaan ^{[2
]}

Yu, Yongping ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China

[2] Zhejiang Sci Tech Univ, Dept Chem, Hangzhou 310018, Zhejiang, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2017年 / 4卷 / 06期

基金：

中国国家自然科学基金;

关键词：

BOND FORMATION; POTASSIUM THIOCYANATE; DIVERGENT SYNTHESIS; SULFINIC ACIDS; DERIVATIVES; ALKENES; SULFONYLHYDRAZIDES; SULFONYLATION; CYCLIZATION; IMIDAZOLES;

D O I：

10.1039/c6qo00756b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Transition metal-free oxidative coupling of vinyl azides with sulfonyl hydrazines is described. This radical process realized oxidative multi-functionalization of vinyl azides in the presence of potassium iodide and t-butyl hydroperoxide, selectively yielding beta-keto sulfones and alpha-halo-beta-keto sulfones in good to excellent yields with a wide tolerance of functional groups.

引用

页码：1162 / 1166

页数：5

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