Phylogeny estimation and hypothesis testing using maximum likelihood

被引：853

作者：

Huelsenbeck, JP ^{[1
]}

Crandall, KA

机构：

[1] Univ Rochester, Dept Biol, Rochester, NY 14627 USA

[2] Brigham Young Univ, Dept Zool, Provo, UT 84602 USA

[3] Brigham Young Univ, ML Bean Museum, Provo, UT 84602 USA

来源：

ANNUAL REVIEW OF ECOLOGY AND SYSTEMATICS | 1997年 / 28卷

关键词：

maximum likelihood; phylogeny; hypothesis test; evolutionary model; molecular evolution;

D O I：

10.1146/annurev.ecolsys.28.1.437

中图分类号：

Q14 [生态学（生物生态学）];

学科分类号：

071012 ; 0713 ;

摘要：

One of the strengths of the maximum likelihood method of phylogenetic estimation is the ease with which hypotheses can be formulated and tested. Maximum likelihood analysis of DNA and amino acid sequence data has been made practical with recent advances in models of DNA substitution, computer programs, and computational speed. Here, we describe the maximum likelihood method and the recent improvements in models of substitution. We also describe how likelihood ratio tests of a variety of biological hypotheses can be formulated and tested using computer simulation to generate the null distribution of the likelihood ratio test statistic.

引用

页码：437 / 466

页数：30

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