The lymphocyte guard-IANs: regulation of lymphocyte survival by IAN/GIMAP family proteins

被引：82

作者：

Nitta, Takeshi ^{[1
]}

Takahama, Yousuke ^{[1
]}

机构：

[1] Univ Tokushima, Inst Genome Res, Div Expt Immunol, Tokushima 7708503, Japan

来源：

TRENDS IN IMMUNOLOGY | 2007年 / 28卷 / 02期

基金：

日本学术振兴会;

关键词：

T-CELL DEVELOPMENT; RECENT THYMIC EMIGRANTS; NEGATIVE SELECTION; BB RAT; BCL-2; FAMILY; BH3-ONLY PROTEINS; BAX TRANSLOCATION; HUMAN ORTHOLOG; GENE; DEATH;

D O I：

10.1016/j.it.2006.12.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The life-or-death decision of immune cells makes an essential contribution to immune-system development and the regulation of immune responses. A new family of cell-survival regulators expressed in lymphocytes, termed immune-associated nucleotide-binding proteins OANs) [also known as GTPase of immunity-associated proteins (GIMAPs)], has been described. The IAN/GIMAP family consists of GTP-binding proteins that share a unique primary structure and whose expression is finely regulated by T-cell receptor signals. Recent studies have shown that IAN/GIMAP family proteins crucially regulate the survival of T cells during development, selection and homeostasis, and are possibly linked to the onset of T-lymphopenia, leukemia and autoimmunity. IAN/ GIMAP family proteins might also take part in mitochondrial regulation of lymphocyte apoptosis by interacting with Bcl-2 family proteins.

引用

页码：58 / 65

页数：8

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