The lymphocyte guard-IANs: regulation of lymphocyte survival by IAN/GIMAP family proteins

被引：82

作者：

Nitta, Takeshi ^{[1
]}

Takahama, Yousuke ^{[1
]}

机构：

[1] Univ Tokushima, Inst Genome Res, Div Expt Immunol, Tokushima 7708503, Japan

来源：

TRENDS IN IMMUNOLOGY | 2007年 / 28卷 / 02期

基金：

日本学术振兴会;

关键词：

T-CELL DEVELOPMENT; RECENT THYMIC EMIGRANTS; NEGATIVE SELECTION; BB RAT; BCL-2; FAMILY; BH3-ONLY PROTEINS; BAX TRANSLOCATION; HUMAN ORTHOLOG; GENE; DEATH;

D O I：

10.1016/j.it.2006.12.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The life-or-death decision of immune cells makes an essential contribution to immune-system development and the regulation of immune responses. A new family of cell-survival regulators expressed in lymphocytes, termed immune-associated nucleotide-binding proteins OANs) [also known as GTPase of immunity-associated proteins (GIMAPs)], has been described. The IAN/GIMAP family consists of GTP-binding proteins that share a unique primary structure and whose expression is finely regulated by T-cell receptor signals. Recent studies have shown that IAN/GIMAP family proteins crucially regulate the survival of T cells during development, selection and homeostasis, and are possibly linked to the onset of T-lymphopenia, leukemia and autoimmunity. IAN/ GIMAP family proteins might also take part in mitochondrial regulation of lymphocyte apoptosis by interacting with Bcl-2 family proteins.

引用

页码：58 / 65

页数：8

共 67 条

[1] The antiapoptotic gene Ian4l1 in the rat: genomic organization and promoter characterization [J].

Andersen, UN ;

Markholst, H ;

Hornum, L .

GENE, 2004, 341 :141-148

[2] BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes [J].

Bouillet, P ;

Purton, JF ;

Godfrey, DI ;

Zhang, LC ;

Coultas, L ;

Puthalakath, H ;

Pellegrini, M ;

Cory, S ;

Adams, JM ;

Strasser, A .

NATURE, 2002, 415 (6874) :922-926

[3] Regulation of Bim by TCR signals in CD4/CD8 double-positive thymocytes [J].

Bunin, A ;

Khwaja, FW ;

Kersh, GJ .

JOURNAL OF IMMUNOLOGY, 2005, 175 (03) :1532-1539

[4] Human Immune Associated Nucleotide 1:: a member of a new guanosine triphosphatase family expressed in resting T and B cells [J].

Cambot, M ;

Aresta, S ;

Kahn-Perlès, B ;

de Gunzburg, J ;

Roméo, PH .

BLOOD, 2002, 99 (09) :3293-3301

[5] The Bcl-2 family: roles in cell survival and oncogenesis [J].

Cory, S ;

Huang, DCS ;

Adams, JM .

ONCOGENE, 2003, 22 (53) :8590-8607

[6] Eosinophilic bowel disease controlled by the BB rat-derived lymphopenia/Gimap5 gene [J].

Cousins, Lesley ;

Graham, Margaret ;

Tooze, Reuben ;

Carter, Christine ;

Miller, J. Ross ;

Powrie, Fiona M. ;

Macpherson, Gordon G. ;

Butcher, Geoffrey W. .

GASTROENTEROLOGY, 2006, 131 (05) :1475-1485

[7] Molecular cloning of Ian4:: a BCR/ABL-induced gene that encodes an outer membrane mitochondrial protein with GTP-binding activity [J].

Dahéron, L ;

Zenz, T ;

Siracusa, LD ;

Brenner, C ;

Calabretta, B .

NUCLEIC ACIDS RESEARCH, 2001, 29 (06) :1308-1316

[8] Expression of the Ian family of putative GTPases during T cell development and description of an Ian with three sets of GTP/GDP-binding motifs [J].

Dion, C ;

Carter, C ;

Hepburn, L ;

Coadwell, WJ ;

Morgan, G ;

Graham, M ;

Pugh, N ;

Anderson, G ;

Butcher, GW ;

Miller, JR .

INTERNATIONAL IMMUNOLOGY, 2005, 17 (09) :1257-1268

[9] Role of Bcl-2 family members in immunity and disease [J].

Droin, NM ;

Green, DR .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2004, 1644 (2-3) :179-188

[10]

Groen H, 1996, J IMMUNOL, V156, P1269

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