Abnormal spontaneous regional brain activity in primary insomnia: a resting-state functional magnetic resonance imaging study

被引：76

作者：

Li, Chao ^{[1
]}

Ma, Xiaofen ^{[2
]}

Dong, Mengshi ^{[2
]}

Yin, Yi ^{[1
]}

Hua, Kelei ^{[1
]}

Li, Meng ^{[2
]}

Li, Changhong ^{[2
]}

Zhan, Wenfeng ^{[2
]}

Li, Cheng ^{[2
,3
]}

Jiang, Guihua ^{[2
]}

机构：

[1] Southern Med Univ, Clin Med Coll 3, Affiliated Guangdong Prov Peoples Hosp 2, Dept Med Imaging, Guangzhou 510317, Guangdong, Peoples R China

[2] Southern Med Univ, Dept Med Imaging, Affiliated Guangdong Prov Peoples Hosp 2, Guangzhou 510317, Guangdong, Peoples R China

[3] Southern Med Univ, Affiliated Guangdong Prov Peoples Hosp 2, Dept Renal Transplantat, Guangzhou 510317, Guangdong, Peoples R China

来源：

NEUROPSYCHIATRIC DISEASE AND TREATMENT | 2016年 / 12卷

基金：

中国国家自然科学基金;

关键词：

primary insomnia; amplitude of low frequency fluctuations; resting-state fMRI; spontaneous brain activity; GENDER-DIFFERENCES; SLEEP-DEPRIVATION; DEFAULT MODE; CONNECTIVITY; FMRI; DISSOCIATION; PERFORMANCE; CEREBELLUM; DISORDER; MRI;

D O I：

10.2147/NDT.S109633

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: Investigating functional specialization is crucial for a complete understanding of the neural mechanisms of primary insomnia (PI). Resting-state functional magnetic resonance imaging (fMRI) is a useful tool to explore the functional specialization of PI. However, only a few studies have focused on the functional specialization of PI using resting-state fMRI and results of these studies were far from consistent. Thus, the current study aimed to investigate functional specialization of PI using resting-state fMRI with amplitude of low frequency fluctuations (ALFFs) algorithm. Methods: In this study, 55 PI patients and 44 healthy controls were included. ALFF values were compared between the two groups using two-sample t-test. The relationship of abnormal ALFF values with clinical characteristics and duration of insomnia was investigated using Pearson's correlation analysis. Results: PI patients showed lower ALFF values in the left orbitofrontal cortex/inferior frontal gyrus, right middle frontal gyrus, left inferior parietal lobule, and bilateral cerebellum posterior lobes, while higher ALFF values in the right middle/inferior temporal that extended to the right occipital lobe. In addition, we found that the duration of PI negatively correlated with ALFF values in the left orbitofrontal cortex/inferior frontal gyrus, and the Pittsburgh Sleep Quality Index score negatively correlated with ALFF values in the left inferior parietal lobule. Conclusion: The present study added information to limited studies on functional specialization and provided evidence for hyperarousal hypothesis in PI.

引用

页码：1371 / 1378

页数：8

共 37 条

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