Copper-catalyzed C(sp3)-H/N-H Cross Dehydrogenative Coupling Between Toluene Derivatives and Picolinamides

被引：2

作者：

Ji, Huihui ^{[1
]}

Zhan, Hongju ^{[2
]}

Chen, Shumin ^{[2
]}

Fang, Zeguo ^{[1
]}

Zhang, Qian ^{[1
]}

Li, Dong ^{[1
,2
]}

机构：

[1] Hubei Univ Technol, New Mat & Green Mfg Talent Intro & Innovat Demons, Sch Mat & Chem Engn, Wuhan 430068, Peoples R China

[2] Jingchu Univ Technol, Hubei Prov Key Lab Drug Synth & Optimizat, Jingmen 448000, Peoples R China

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 11卷 / 10期

关键词：

amidation; benzylic C-H bond; copper; cross dehydrogenative coupling; toluene; C-H AMINATION; BOND FORMATION; INTRAMOLECULAR AMINATION; BENZYLIC HYDROCARBONS; CARBOXYLIC-ACIDS; N-METHYLATION; SIMPLE ETHERS; AMIDATION; FUNCTIONALIZATION; AMIDES;

D O I：

10.1002/ajoc.202200454

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient C-N bond formation method through copper-catalyzed C(sp3)-H/N-H cross dehydrogenative coupling between toluene derivatives and picolinamides was developed. The N-H bond of picolinamides was activated by the direction of pyridyl group without influence of remote C-H bonds. The method was applicable to a broad range of substrates with good functional group compatibility, which provided a novel route to prepare N-benzyl tertiary amides from cheap and readily available starting materials.

引用

页数：5

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